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We're creating and deploying a software framework (NextCR, comprising software code, documentation, training materials) that organisations can use to establish and operate highly secure, cloud-based next-generation clinical registries. It will address new national requirements for clinical quality registries in domains including orthopaedics, cardiovascular disease and cancer. It will use advanced software engineering and AI methods to transform near real-time data drawn directly from electronic medical records (EMRs) and other electronic data, including imaging. NextCR registries will provide highly-detailed, research-ready clinical data, leveraging international Common Data Models and terminologies to maximise data interoperability.