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Dr Ashwin Unnikrishnan

Dr Ashwin Unnikrishnan

Senior Lecturer
Medicine & Health
School of Clinical Medicine

I am a biomedical research scientist and Head of the Molecular Mechanisms in Leukaemia laboratory (/medicine-health/our-schools/clinical-medicine/research-impact/research-groups/cancer/molecular-mechanisms-leukaemia-lab) at the Lowy Cancer Research Centre, University of New South Wales.


My lab uses a combination of genomics, epigenomics, molecular biology and stem cell biology techniques to understand the mechanisms driving leukaemia, as well as those underpinning resistance to therapy. Our research interests are strongly geared towards translational medical outcomes.


We are always looking for talented, motivated scientists and students, so please get in touch (Twitter/LinkedIn/email) if you are interested in discussing opportunities in my lab.
Phone
+61 2 93858045
E-mail
ashwin.unnikrishnan@unsw.edu.au
Location
Adult Cancer Program, Level 2, Lowy Cancer Research Centre, University of New South Wales
  • Book Chapters | 2010
    Tsukiyama T; Bogenschutz N; Kwong T; Rodriguez J; Unnikrishnan A; Yadon A, 2010, 'Chapter 283 ISWI Chromatin Remodeling Complexes', in Handbook of Cell Signaling, Elsevier, pp. 2357 - 2362,
    Book Chapters | 2009
    Tsukiyama T; Bogenschutz N; Kwong T; Rodriguez J; Unnikrishnan A, 2009, 'ISWI Chromatin Remodeling Complexes', in Bradshaw RA; Dennis EA (ed.), Handbook of Cell Signaling (Second Edition), Academic Press, Oxford, pp. 2357 - 2362,
  • Journal articles | 2023
    Schnegg-Kaufmann AS; Thoms JAI; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson Beves EMV; Failes TW; Arndt GM; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Davidson S; Polizzotto MN; Hertzberg M; Papaemmanuil E; Bohlander SK; Faridani OR; Jolly CJ; Zanini F; Pimanda JE, 2023, 'Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy', Blood, 141, pp. 1316 - 1321,
    Journal articles | 2022
    Amaldoss MJN; Mehmood R; Yang JL; Koshy P; Kumar N; Unnikrishnan A; Sorrell CC, 2022, 'Anticancer therapeutic effect of cerium-based nanoparticles: known and unknown molecular mechanisms', Biomaterials Science, 10, pp. 3671 - 3694,
    Journal articles | 2022
    Amaldoss MJN; Pandzic E; Koshy P; Kumar N; Sorrell CC; Unnikrishnan A, 2022, 'Detection and quantification of nanoparticle-induced intracellular ROS in live cells by laser scanning confocal microscopy', Methods, 207, pp. 11 - 19,
    Journal articles | 2022
    Amaldoss MJN; Yang JL; Koshy P; Unnikrishnan A; Sorrell CC, 2022, 'Inorganic nanoparticle-based advanced cancer therapies: Promising combination strategies', Drug Discovery Today, 27,
    Journal articles | 2022
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Olivier J; Joshi S; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver RA; Unnikrishnan A; Carter DR; Lee B; Brownlee C; Power C; Brink R; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda JE, 2022, 'Mesoderm-derived PDGFRA+ cells regulate the emergence of hematopoietic stem cells in the dorsal aorta', Nature Cell Biology, 24, pp. 1211 - 1225,
    Journal articles | 2022
    Liu L; Vujovic A; Deshpande NP; Sathe S; Anande G; Chen HTT; Xu J; Minden MD; Yeo GW; Unnikrishnan A; Hope KJ; Lu Y, 2022, 'The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors', Nature Communications, 13, pp. 3833,
    Journal articles | 2022
    Liu YC; Kwon J; Fabiani E; Xiao Z; Liu YV; Follo MY; Liu J; Huang H; Gao C; Liu J; Falconi G; Valentini L; Gurnari C; Finelli C; Cocco L; Liu JH; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Bassal MA; Voso MT; Tenen DG; Chai L, 2022, 'Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy', New England Journal of Medicine, 386, pp. 1998 - 2010,
    Journal articles | 2022
    Pimanda JE; Thoms JAI; Hampton HR; Davidson S; Joshi S; Sarowar CH; Lim XY; Nunez AC; Kakadia PM; Pickford R; Raftery M; Hough S; Buckland G; Bailey M; Ghodke Y; Absar N; Vaughan L; Pasalic L; Fong CY; Kenealy M; Hiwase D; Stoddart R; Mohammed S; Lee L; Passam FH; Spring K; Skarratt KK; Rebeiro P; Larsen SR; Presgrave P; Stevenson WS; Ling S; Tiley C; Fuller S; Roncolato F; Enjeti AK; Hoenemann D; Lemech C; Bohlander SK; Olivier J; Hertzberg M; Unnikrishnan A; Polizzotto MN, 2022, 'In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial', Blood, 140, pp. 6927 - 6929,
    Journal articles | 2022
    Saini SK; Holmberg-Thydén S; Bjerregaard AM; Unnikrishnan A; Dorfmüller S; Platzbecker U; Tirado-Gonzalez I; Bönig H; El Fassi D; Grønbæk K; Pimanda J; Medyouf H; Hadrup SR, 2022, 'Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies', Leukemia, 36, pp. 2734 - 2738,
    Journal articles | 2022
    Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Henry H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Greg A; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Pappaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, 'P748: SINGLE CELL GENOTYPING OF MATCHED BONE MARROW AND PERIPHERAL BLOOD CELLS IN TREATMENT NAIVE AND AZA-TREATED MDS AND CMML', HemaSphere, 6, pp. 643 - 644,
    Journal articles | 2022
    Thoms JAI; Schnegg-Kaufmann A; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Lee HM; Johansson E; Failes TW; Arndt GM; Koval J; Davidson S; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Hertzberg M; Polizzotto MN; Papaemmanuil E; Bohlander SK; Faridani O; Jolly CJ; Zanini F; Pimanda JE, 2022, 'Clinical Response to Azacytidine (AZA) Is Associated with Increased Contribution from Mutated Blood Progenitors: Insights from Single Cell Genotyping of Matched Stem/Progenitor and Mature Blood Cells from MDS/CMML Patients Pre- and Post-AZA Treatment', Blood, 140, pp. 9751 - 9752,
    Journal articles | 2021
    Chandrakanthan V; Rorimpandey P; Zanini F; Chacon D; Kang YC; Knezevic K; Huang Y; Qiao Q; Oliver R; Unnikrishnan A; Carter D; Lee B; Brownlee C; Power C; Mendez-Ferrer S; Enikolopov G; Walsh W; Göttgens B; Taoudi S; Beck D; Pimanda J, 2021, 'Mesoderm-Derived PDGFRA+Cells Regulate the Emergence of Hematopoietic Stem Cells in the Dorsal Aorta', ,
    Journal articles | 2021
    Liu L; Vujovic A; Deshpande N; Sathe S; Anande G; Xu J; Minden M; Yeo G; Unnikrishnan A; Hope K; Lu Y, 2021, 'RBM17 Mediates Evasion of Pro-Leukemic Factors from Splicing-coupled NMD to Enforce Leukemic Stem Cell Maintenance', ,
    Journal articles | 2021
    Lorenzi L; Chiu HS; Avila Cobos F; Gross S; Volders PJ; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Tay AP; de Bony EJ; Trypsteen W; Gysens F; Vromman M; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande NP; Anande G; Chen TW; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2021, 'Publisher Correction: The RNA Atlas expands the catalog of human non-coding RNAs (Nature Biotechnology, (2021), 39, 11, (1453-1465), 10.1038/s41587-021-00936-1)', Nature Biotechnology, 39, pp. 1467,
    Journal articles | 2021
    Lorenzi L; Chiu HS; Avila Cobos F; Gross S; Volders PJ; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Tay AP; de Bony EJ; Trypsteen W; Gysens F; Vromman M; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande NP; Anande G; Chen TW; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2021, 'The RNA Atlas expands the catalog of human non-coding RNAs', Nature Biotechnology, 39, pp. 1453 - 1465,
    Journal articles | 2021
    Yang J; Gao C; Liu M; Liu YC; Kwon J; Qi J; Tian X; Stein A; Liu YV; Kong NR; Wu Y; Yin S; Xi J; Chen Z; Kumari K; Wong H; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2021, 'Targeting an Inducible SALL4-Mediated Cancer Vulnerability with Sequential Therapy', Cancer Research, 81, pp. 6018 - 6028,
    Journal articles | 2020
    Anande G; Deshpande N; Mareschal S; Batcha A; Hampton H; Herold T; Lehmann S; Wilkins M; Wong JWH; Unnikrishnan A; Pimanda J, 2020, 'RNA splicing alterations induce a cellular stress response associated with poor prognosis in AML', ,
    Journal articles | 2020
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2020, 'RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia', Clinical Cancer Research, 26, pp. 3597 - 3607,
    Journal articles | 2020
    Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2020, 'Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth', Molecular Cancer Research, 18, pp. 709 - 722,
    Journal articles | 2020
    Saini SK; Ørskov A; Bjerregaard A-M; Unnikrishnan A; Holmberg-Thydén S; Borch A; Anande G; Bentzen A; Marquard A; Tamhane T; Gang A; Defva I; Szallasi Z; Eklund A; Pimanda J; Grønbæk K; Hadrup S, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers with low mutational burden', The Journal of Immunology, 204, pp. 242.14 - 242.14,
    Journal articles | 2020
    Saini SK; Ørskov AD; Bjerregaard AM; Unnikrishnan A; Holmberg-Thydén S; Borch A; Jensen KV; Anande G; Bentzen AK; Marquard AM; Tamhane T; Treppendahl MB; Gang AO; Dufva IH; Szallasi Z; Ternette N; Pedersen AG; Eklund AC; Pimanda J; Grønbæk K; Hadrup SR, 2020, 'Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers', Nature Communications, 11, pp. 5660,
    Journal articles | 2019
    Kumar P; Beck D; Galeev R; Thoms JAI; Talkhoncheh MS; de Jong I; Unnikrishnan A; Baudet A; Subramaniam A; Pimanda JE; Larsson J, 2019, 'HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells', Blood Advances, 3, pp. 681 - 691,
    Journal articles | 2018
    Ali A; Penneroux J; Dal Bello R; Massé A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Ben Abdelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Adès L; Puissant A; Itzykson R, 2018, 'Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia', Leukemia, 32, pp. 1856 - 1860,
    Journal articles | 2018
    Smeets MF; Tan SY; Xu JJ; Anande G; Unnikrishnan A; Chalk AM; Taylor SR; Pimanda JE; Wall M; Purton LE; Walkley CR, 2018, 'Srsf2P95H initiates myeloid bias and myelodysplastic/ myeloproliferative syndrome from hemopoietic stem cells', Blood, 132, pp. 608 - 621,
    Journal articles | 2018
    Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910,
    Journal articles | 2017
    Unnikrishnan A; Papaemmanuil E; Beck D; Deshpande NP; Verma A; Kumari A; Woll PS; Richards LA; Knezevic K; Chandrakanthan V; Thoms JAI; Tursky ML; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj AG; Tobiasson M; Karimi M; Pellagatti A; Wilson SR; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; Wilkins MR; MacKenzie KL; Wong JWH; Campbell PJ; Pimanda JE, 2017, 'Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes', Cell Reports, 20, pp. 572 - 585,
    Journal articles | 2016
    Botezatu L; Michel LC; Makishima H; Schroeder T; Germing U; Haas R; Van der Reijden B; Marneth AE; Bergevoet SM; Jansen JH; Przychodzen B; Wlodarski M; Niemeyer C; Platzbecker U; Ehninger G; Unnikrishnan A; Beck D; Pimanda J; Hellström-Lindberg E; Malcovati L; Boultwood J; Pellagatti A; Papaemmanuil E; Le Coutre P; Kaeda J; Opalka B; Möröy T; Dührsen U; Maciejewski J; Khandanpour C, 2016, 'GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome', Experimental Hematology, 44, pp. 590 - 595.e1,
    Journal articles | 2016
    Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315,
    Journal articles | 2016
    Nasrallah R; Fast EM; Solaimani P; Knezevic K; Eliades A; Patel R; Thambyrajah R; Unnikrishnan A; Thoms J; Beck D; Vink CS; Smith A; Wong J; Shepherd M; Kent D; Roychoudhuri R; Paul F; Klippert J; Hammes A; Willnow T; Göttgens B; Dzierzak E; Zon LI; Lacaud G; Kouskoff V; Pimanda JE, 2016, 'Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes', Blood, 128, pp. 1928 - 1939,
    Journal articles | 2016
    Poulos RC; Thoms JAI; Guan YF; Unnikrishnan A; Pimanda JE; Wong JWH, 2016, 'Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif', Cell Reports, 17, pp. 2865 - 2872,
    Journal articles | 2016
    Unnikrishnan A; Guan YF; Huang Y; Beck D; Thoms JAI; Peirs S; Knezevic K; Ma S; De Walle IV; De Jong IDE; Ali Z; Zhong L; Raftery MJ; Taghon T; Larsson J; MacKenzie KL; Van Vlierberghe P; Wong JWH; Pimanda JE, 2016, 'A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network', Nucleic Acids Research, 44, pp. 10644 - 10661,
    Journal articles | 2015
    Lacramioara B; Makishima H; Michel L; Hoenes J; Marneth A; van der Reijden B; Radiovoyevich T; Germing U; Haas R; Schroeder T; Vadnais C; Helness A; Pimanda J; Jansen J; Unnikrishnan A; Platzbecker U; Papaemmanuil E; Ehninger G; Moroy T; Duhrsen U; Maciejewski J; Khandanpour C, 2015, '72 PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', Leukemia Research, 39, pp. S35 - S35,
    Journal articles | 2015
    Tursky ML; Beck D; Thoms JAI; Huang Y; Kumari A; Unnikrishnan A; Knezevic K; Evans K; Richards LA; Lee E; Morris J; Goldberg L; Izraeli S; Wong JWH; Olivier J; Lock RB; MacKenzie KL; Pimanda JE, 2015, 'Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias', Leukemia, 29, pp. 819 - 827,
    Journal articles | 2015
    Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 27, pp. 603 - 605,
    Journal articles | 2015
    Woll PS; Kjällquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark SA; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Göhring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellström-Lindberg E; Linnarsson S; Jacobsen SEW, 2015, 'Erratum to Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo, [Cancer Cell, 25, 2014, 794-808]', Cancer Cell, 27, pp. 603 - 605,
    Journal articles | 2014
    Ju YSE; Alexandrov LB; Gerstung M; Martincorena I; Nik-Zainal S; Ramakrishna M; Davies HR; Papaemmanuil E; Gundem G; Shlien A; Bolli N; Behjati S; Tarpey PS; Nangalia J; Massie CE; Butler AP; Teague JW; Vassiliou GS; Green AR; Du MQ; Unnikrishnan A; Pimanda JE; Teh BTE; Munshi N; Greaves M; Vyas P; El-Naggar AK; Santarius T; Collins VP; Grundy R; Taylor JA; Hayes DN; Malkin D; Foster CS; Warren AY; Whitaker HC; Brewer D; Eeles R; Cooper C; Neal D; Visakorpi T; Isaacs WB; Bova GS; Flanagan AM; Futreal PA; Lynch AG; Chinnery PF; McDermott U; Stratton MR; Campbell PJ, 2014, 'Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer', eLife, 3, pp. e02935,
    Journal articles | 2014
    Tobiasson M; Karimi M; Dimitriou M; Qu Y; Lennartsson A; Ali HA; Unnikrishnan A; Jadersten M; Jansson M; Ben Azenkoud A; Pimanda JE; Ekwall K; Ungerstedt J; Lehmann S; Hellstrom-Lindberg E, 2014, 'Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients', BLOOD, 124,
    Journal articles | 2014
    Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW, 2014, 'Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)', CANCER CELL, 25, pp. 861 - 861,
    Journal articles | 2013
    Beck D; Thoms JAI; Perera D; Schütte J; Unnikrishnan A; Knezevic K; Kinston SJ; Wilson NK; O'Brien TA; Göttgens B; Wong JWH; Pimanda JE, 2013, 'Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes', Blood, 122, pp. e12 - e22,
    Journal articles | 2012
    Beck D; Brandl MB; boelen L; Unnikrishnan A; Pimanda JE; Wong JWH, 2012, 'Signal analysis for genome-wide maps of histone modifications measured by ChIP-seq', Bioinformatics, 28, pp. 1062 - 1069
    Journal articles | 2012
    Unnikrishnan A; Akiyoshi B; Biggins S; Tsukiyama T, 2012, 'An efficient purification system for native minichromosome from Saccharomyces cerevisiae', Methods in Molecular Biology, 833, pp. 115 - 123,
    Journal articles | 2010
    Unnikrishnan A; Gafken PR; Tsukiyama T, 2010, 'Dynamic changes in histone acetylation regulate origins of DNA replication', Nature Structural & Molecular Biology, 17, pp. 430 - 437,
  • Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Data from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 1 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 1 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 2 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 3 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Anande G; Deshpande NP; Mareschal S; Batcha AMN; Hampton HR; Herold T; Lehmann S; Wilkins MR; Wong JWH; Unnikrishnan A; Pimanda JE, 2023, Supplementary Figure 4 from RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia,
    Other | 2023
    Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2023, Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth, ,
    Other | 2023
    Khanna A; Thoms JAI; Stringer BW; Chung SA; Ensbey KS; Jue TR; Jahan Z; Subramanian S; Anande G; Shen H; Unnikrishnan A; McDonald KL; Day BW; Pimanda JE, 2023, Supplementary methods and figures from Constitutive CHK1 Expression Drives a pSTAT3–CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth, ,
    Preprints | 2023
    Tan S; Joseph C; Chalk AM; Hendy J; Fabb S; Schleibs K; Lee SC; Tjin G; Grace CS; Madugalle V; Smeets MF; Maluenda AC; Rice KL; Baker EK; Nandurkar H; Slape CI; Parker MW; Unnikrishnan A; Mufti GJ; Tobiasson M; Hellstrom-Lindberg E; Pimanda JE; Gudas LJ; Holien JK; Walkley CR; Wall M; Purton LE, 2023, Dysregulated expression ofHoxa1isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes, ,
    Preprints | 2022
    Schnegg-Kaufmann A; Thoms J; Bhuyan GS; Hampton H; Vaughan L; Rutherford K; Kakadia P; Johansson E; Failes T; Arndt G; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead A; Unnikrishnan A; Bohlander S; Papaemmanuil E; Faridani O; Jolly C; Zanini F; Pimanda J, 2022, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML,
    Conference Papers | 2021
    Roels J; De Decker M; Gaffo E; Anande G; Thandapani P; Bohme L; Van Hulle J; Derveeuw A; Velghe I; Van Droogenbroeck Y; Putteman T; Buratin A; Deshpande N; Unnikrishnan A; Bortoluzzi S; Aifantis I; Van Vlierberghe P; Taghon T, 2021, 'An integrated multi-omics view on human T cell development', in EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY, pp. 52 - 52,
    Preprints | 2020
    Liu Y-C; Fabiani E; Kwon J; Gao C; Falconi G; Valentini L; Gurnari C; Liu YV; Jones AI; Yang J; Yang H; Thoms JAI; Unnikrishnan A; Pimanda JE; Pan R; Voso MT; Tenen DG; Chai L, 2020, Demethylation and upregulation of an oncogene post hypomethylating treatment,
    Preprints | 2020
    Yang J; Gao C; Liu M; Chen Z; Liu Y-C; Kwon J; Qi J; Tian X; Stein A; Liu Y; Kong NR; Wu Y; Yin S; Xi JJ; Luo H; Silberstein LE; Thoms JAI; Unnikrishnan A; Pimanda JE; Tenen DG; Chai L, 2020, Induction of a SALL4-dependency for targeted cancer therapy,
    Conference Papers | 2019
    Anande G; Unnikrishnan A; Deshpande N; Mareschal S; Batcha AMN; Herold T; Lehmann S; Wilkins M; Wong J; Pimanda J, 2019, 'Identification of Recurrent Alternative RNA Splicing in Adverse-Risk Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019,
    Preprints | 2019
    Lorenzi L; Chiu H-S; Cobos FA; Gross S; Volders P-J; Cannoodt R; Nuytens J; Vanderheyden K; Anckaert J; Lefever S; Goovaerts T; Hansen TB; Kuersten S; Nijs N; Taghon T; Vermaelen K; Bracke KR; Saeys Y; De Meyer T; Deshpande N; Anande G; Chen T-W; Wilkins MR; Unnikrishnan A; De Preter K; Kjems J; Koster J; Schroth GP; Vandesompele J; Sumazin P; Mestdagh P, 2019, The RNA Atlas, a single nucleotide resolution map of the human transcriptome,
    Conference Papers | 2019
    Saini SK; Bjerregaard A-M; Orskov AD; Unnikrishnan A; Holmberg S; Anande G; Bentzen AK; Szallasi Z; Eklund AC; Gronbaek K; Hadrup SR, 2019, 'Human endogenous retroviruses as a potential reservoir for T-cell mediated cancer immunotherapy', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH,
    Conference Papers | 2019
    Unnikrishnan A; Lim XY; Joshi S; Nunez AC; Vaughan L; Pickford R; Hough S; Davidson S; Fong C; Kenealy M; Hiwase DK; Pasalic L; Mohammed S; Lee L; Passam FH; Spring K; Rebeiro P; Ling S; Fuller S; Presgrave P; Roncolato F; Larsen S; Enjeti AK; Stevenson WS; Tiley C; Campbell PJ; Lemech C; Olivier J; Hertzberg M; Polizzotto MN; Pimanda J, 2019, 'In Vivo Assessment of Intracellular Dynamics Comparing Injection Versus Oral Azacitidine in a Phase IIb Investigator Initiated Clinical Trial', in BLOOD, AMER SOC HEMATOLOGY, FL, Orlando, presented at 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), FL, Orlando, 07 December 2019 - 10 December 2019,
    Conference Abstracts | 2018
    Sonderegger S; Cerruti L; Tremblay C; Toulmin E; Saw J; Nebl T; Hannan KM; Lane SW; Falk H; Unnikrishnan A; Stupple P; Street I; Jane S; Altura R; Nicholson B; Curtis DJ, 2018, 'Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, Vol. 132, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018,
    Conference Papers | 2017
    Ali A; Penneroux J; Dal Bello R; Masse A; Quentin S; Unnikrishnan A; Hernandez L; Raffoux E; Benabelali R; Renneville A; Preudhomme C; Pimanda J; Dombret H; Soulier J; Fenaux P; Clappier E; Ades L; Itzykson R, 2017, 'Granulomonocytic Progenitors (GMPs) Are Key Target Cells of Azacitidine in MDS and AML', in BLOOD, AMER SOC HEMATOLOGY, GA, Atlanta, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), GA, Atlanta, 09 December 2017 - 12 December 2017,
    Conference Presentations | 2017
    Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver R; Unnikrishnan A; Huang Y; Walsh W; Lee B; Lee CB; Power C; Beck D; Taoudi S; Pimanda J, 2017, 'DECLINED PRESENTATION MESENCHYMAL STEM CELL-LIKE CELL MEDIATED HEMATOPOIETIC STEM CELL GENERATION FROM NON-HEMOGENIC ENDOTHELIAL CELLS',
    Conference Proceedings (Editor of) | 2017
    Chandrakanthan V; Kang YC; Knezevic K; Qiao Q; Oliver RA; Unnikrishnan A; Beck D; Lee B; Brownlee C; Power C; Pimanda JE, 2017, 'Genetic Fate Mapping of Mesenchymal Stem-Like Cells in the Aorta-Gonad Mesonephros (AGM) and Their Contribution to Definitive Hematopoiesis', ELSEVIER SCIENCE BV, SINGAPORE, Natil Univ Singapore, Singapore, Vol. 145, presented at 18th International Congress of Developmental Biology, SINGAPORE, Natil Univ Singapore, Singapore, 18 June 2017 - 22 June 2017,
    Conference Abstracts | 2017
    Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017
    Conference Abstracts | 2016
    Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315,
    Conference Abstracts | 2016
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky M; Huang Y; Ali Z; Olivier J; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'INTEGRATIVE GENOMICS IDENTIFIES THE MOLECULAR BASIS OF RESISTANCE TO AZACITIDINE THERAPY IN MYELODYSPLASTIC SYNDROMES', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, DENMARK, Copenhagen, Vol. 101, pp. 157 - 158, presented at 21st Congress of the European-Hematology-Association, DENMARK, Copenhagen, 09 June 2016 - 12 June 2016,
    Conference Papers | 2016
    Unnikrishnan A; Papaemmanuil E; Beck D; Verma A; Kumari A; Woll P; Richards L; Knezevic K; Chandrakanthan V; Thoms J; Tursky ML; Huang Y; Ali Z; Olivier S; Galbraith S; Kulasekararaj A; Tobiasson M; Karimi M; Pellagatti A; Wilson S; Lindeman R; Young B; Ramakrishna R; Arthur C; Stark R; Crispin P; Curnow J; Warburton P; Roncolato F; Boultwood J; Lynch K; Jacobsen S; Mufti G; Hellstrom-Lindberg E; MacKenzie K; Wong J; Campbell P; Pimanda J, 2016, 'Integrative genomics identifies the molecular basis of resistance to Azacitidine therapy in Myelodysplastic Syndromes', Ferrata Storti Foundation, Copenhagen, Denmark, pp. 157 - 158, presented at 21st Congress Of The European Hematology Association (EHA), Copenhagen, Denmark, 09 June 2016 - 12 June 2016,
    Conference Papers | 2015
    Lacramioara B; Makishima H; Michel L; Hoenes J; Marneth A; van der Reijden B; Radiovoyevich T; Germing U; Haas R; Schroeder T; Vadnais C; Helness A; Pimanda J; Jansen J; Unnikrishnan A; Platzbecker U; Papaemmanuil E; Ehninger G; Moroy T; Duhrsen U; Maciejewski J; Khandanpour C, 2015, 'PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS', in LEUKEMIA RESEARCH, PERGAMON-ELSEVIER SCIENCE LTD, DC, Washington, pp. S35 - S35, presented at 13th International Symposium on Myelodysplastic Syndromes (MDS), DC, Washington, 29 April 2015 - 02 May 2015,
    Conference Papers | 2015
    Unnikrishnan A; Papaemmanuil E; Beck D; Kumari A, 2015, 'An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML', in An Integrative Genomics Approach Uncovers the Basis of Resistance to, USA, presented at ASH Annual Meeting, USA, 05 December 2015 - 08 December 2015
    Conference Papers | 2014
    Unnikrishnan A; Beck D; Verma A; Richards LA; Thoms JAI; Kumari A; Galbraith S; Kulasekararaj A; Tobiasson M; Woll PS; Pellagatti A; Papaemmanuil E; Wilson SR; Lindeman R; Campbell PJ; Boultwood J; Lynch K; Jacobsen SEW; Mufti GJ; Hellstrom-Lindberg E; MacKenzie KL; Wong JWH; Pimanda JE, 2014, 'Identification of a Prognostic Gene Expression Signature for AZA Response in MDS and CMML Patients', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014,
    Conference Papers | 2013
    Beck D; Thoms J; Perera D; Unnikrishnan A; Knezevic K; O'Brien T; Gottgens B; Wong J; Pimanda J, 2013, 'GENOME-WIDE ANALYSIS OF TRANSCRIPTIONAL REGULATORS IN HUMAN HSCS REVEALS A DENSELY INTERCONNECTED NETWORK OF CODING AND NON-CODING GENES', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, AUSTRIA, Vienna, pp. S17 - S17, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), AUSTRIA, Vienna, 22 August 2013 - 25 August 2013,
    Conference Papers | 2013
    Donald MR; Unnikrishnan A; Pimanda JE; Wilson S, 2013, 'Model Comparisons for RNA-Seq Data', in Proceedings of the 28th International Workshop on Statistical Modelling, Palermo, Italy, pp. 563 - 566, presented at 28th International Workshop on Statistical Modelling, Palermo, Italy, 08 July 2013 - 12 July 2014

My Research Supervision

Postdoctoral researchers:

Dr. Govardhan Anande

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Higher Degree Students:

Dr. Lachlin Vaughan (Haematologist, PhD Student)

Newton AmaldossÌý(UNSW Scientia PhD Student)

Onkar Mulay (Masters Student)

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Undergraduate Students:

Rohan Barar (Undergraduate Medical Student, Honours)

Beau Jesser (School of Medical Sciences, Honours)

Jungmin RyuÌý(School of Medical Sciences, Honours)

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Research Staff:

Mangalangi Udayakumar

Lizzie Richardson

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