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Doctor David Jacques

Doctor David Jacques

Scientia Fellow (Level C)

PhD, BSc (Advanced) (Hons)

Medicine & Health
School of Biomedical Sciences

David leads the Structural Virology Group at the EMBL Australia Node for Single Molecule Science. Having completed a bachelor of science majoring in biochemistry and chemistry, David undertook his PhD under the supervision of Professors Jill Trewhella and Mitchell Guss at the University of Sydney. During that time, David employed both crystallography and small-angle scattering to understand protein structure. He also authored the internationally accepted standards by which biological small-angle scattering data are now reported in publications. In 2012, the award of an NHMRC Early Career Fellowship enabled him to join the group of Leo James at the MRC Laboratory of Molecular Biology, Cambridge. Here he studied the role played by the HIV capsid during the early stage of infection, revealing structural dynamics and interactions with the host at a molecular level not previously seen. Since returning to Australia, David leads an independent research team focused on understanding the molecular details of host-pathogen interactions through the use of crystallographic, single molecule fluorescence, and cryo-electron microscopy methods.

Phone
+61 2 9385 8109
Location
Lowy Cancer Centre Building, Level 3
  • Journal articles | 2024
    Dickson CF; Hertel S; Tuckwell AJ; Li N; Ruan J; Al-Izzi SC; Ariotti N; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2024, 'The HIV capsid mimics karyopherin engagement of FG-nucleoporins', Nature, 626, pp. 836 - 842,
    Journal articles | 2024
    Faysal KMR; Walsh JC; Renner N; Márquez CL; Shah VB; Tuckwell AJ; Christie MP; Parker MW; Turville SG; Towers GJ; James LC; Jacques DA; Böcking T, 2024, 'Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure', eLife, 13,
    Journal articles | 2023
    Speck P; MacKenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peter J; Kriiger-Loteri R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse"', mSphere, 8,
    Journal articles | 2023
    Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope-a Call for Rational Discourseâ€', Journal of Virology, 97,
    Journal articles | 2023
    Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope—a Call for Rational Discourseâ€', mBio, 14,
    Journal articles | 2022
    Zhang MJ; Stear JH; Jacques DA; Böcking T, 2022, 'Insights into HIV uncoating from single-particle imaging techniques', Biophysical Reviews, 14, pp. 23 - 32,
    Journal articles | 2022
    Zuliani-Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Rifat Faysal KM; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, 'Evasion of cGAS and TRIM5 defines pandemic HIV', Nature Microbiology, 7, pp. 1762 - 1776,
    Journal articles | 2021
    Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, 93, pp. 3786 - 3793,
    Journal articles | 2021
    Moustaqil M; Ollivier E; Chiu HP; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg AN; Jacques D; Lee B; Sierecki E; Gambin Y, 2021, 'SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species', Emerging Microbes and Infections, 10, pp. 178 - 195,
    Journal articles | 2021
    Renner N; Mallery DL; Faysal KMR; Peng W; Jacques DA; Böcking T; James LC, 2021, 'A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly', PLoS Pathogens, 17, pp. 1 - 22,
    Journal articles | 2021
    Zeng J; Santos AF; Mukadam AS; Osswald M; Jacques DA; Dickson CF; McLaughlin SH; Johnson CM; Kiss L; Luptak J; Renner N; Vaysburd M; McEwan WA; Morais-de-Sá E; Clift D; James LC, 2021, 'Target-induced clustering activates Trim-Away of pathogens and proteins', Nature Structural and Molecular Biology, 28, pp. 278 - 289,
    Journal articles | 2020
    Lau D; Walsh JC; Mousapasandi A; Ariotti N; Shah VB; Turville S; Jacques DA; Böcking T, 2020, 'Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders', Langmuir, 36, pp. 3624 - 3632,
    Journal articles | 2020
    Miles RJ; Kerridge C; Hilditch L; Monit C; Jacques DA; Towers GJ, 2020, 'Mxb sensitivity of HIV-1 is determined by a highly variable and dynamic capsid surface', eLife, 9, pp. 1 - 17,
    Journal articles | 2020
    Moustaqil M; Ollivier E; Chiu H-P; Van Tol S; Rudolffi-Soto P; Stevens C; Bhumkar A; Hunter DJB; Freiberg A; Jacques D; Lee B; Sierecki E; Gambin Y, 2020, 'SARS-CoV-2 proteases cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species and the search for reservoir hosts', ,
    Journal articles | 2020
    Zeng J; Santos AF; Mukadam A; Osswald M; Luptak J; Jacques D; Dickson C; Renner N; Johnson C; Vaysburd M; McEwan W; Morais-de-Sá E; Clift D; James L, 2020, 'Substrate-induced clustering activates Trim-Away of pathogens and proteins', ,
    Journal articles | 2019
    Lau D; Walsh J; Peng W; Shah V; Turville S; Jacques D; Böcking T, 2019, 'Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes', ,
    Journal articles | 2019
    Lau D; Walsh JC; Peng W; Shah VB; Turville S; Jacques DA; Böcking T, 2019, 'Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes', ACS Applied Materials and Interfaces, 11, pp. 34586 - 34594,
    Journal articles | 2018
    James LC; Jacques DA, 2018, 'The human immunodeficiency virus capsid is more than just a genome package', Annual Review of Virology, 5, pp. 209 - 225,
    Journal articles | 2018
    Mallery DL; Márquez CL; McEwan WA; Dickson CF; Jacques DA; Anandapadamanaban M; Bichel K; Towers GJ; Saiardi A; Böcking T; James LC, 2018, 'IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis', eLife, 7,
    Journal articles | 2018
    Márquez CL; Lau D; Walsh J; Shah V; McGuinness C; Wong A; Aggarwal A; Parker MW; Jacques DA; Turville S; Böcking T, 2018, 'Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis', eLife, 7,
    Journal articles | 2017
    Bhati M; Llamosas E; Jacques DA; Jeffries CM; Dastmalchi S; Ripin N; Nicholas HR; Matthews JM, 2017, 'Interactions between LHX3-And ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans', Scientific Reports, 7, pp. 4579,
    Journal articles | 2017
    Trewhella J; Duff AP; Durand D; Gabel F; Guss JM; Hendrickson WA; Hura GL; Jacques DA; Kirby NM; Kwan AH; Pérez J; Pollack L; Ryan TM; Sali A; Schneidman-Duhovny D; Schwede T; Svergun DI; Sugiyama M; Tainer JA; Vachette P; Westbrook J; Whitten AE, 2017, '2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: An update', Acta Crystallographica Section D: Structural Biology, 73, pp. 710 - 728,
    Journal articles | 2016
    Jacques DA; McEwan WA; Hilditch L; Price AJ; Towers GJ; James LC, 2016, 'HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis', Nature, 536, pp. 349 - 353,
    Journal articles | 2015
    Dickson CF; Jacques DA; Clubb RT; Guss JM; Gell DA, 2015, 'The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 1295 - 1306,
    Journal articles | 2015
    Wilkinson-White L; Lester KL; Ripin N; Jacques DA; Mitchell Guss J; Matthews JM, 2015, 'GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA', Protein Science, 24, pp. 1649 - 1659,
    Journal articles | 2015
    Wood K; Jeffries CM; Knott RB; Sokolova A; Jacques DA; Duff AP, 2015, 'Exploring the structure of biological macromolecules in solution using Quokka, the small angle neutron scattering instrument, at ANSTO', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 798, pp. 44 - 51,
    Journal articles | 2014
    Dickson CF; Kumar KK; Jacques DA; Malmirchegini GR; Spirig T; Mackay JP; Clubb RT; Guss JM; Gell DA, 2014, 'Structure of the hemoglobin-isdh complex reveals the molecular basis of iron capture by staphylococcus aureus', Journal of Biological Chemistry, 289, pp. 6728 - 6738,
    Journal articles | 2014
    Jacques D; Jeffries C; Caines M; Lammers M; Mallery D; Price A; McLaughlin S; Johnson C; Svergun D; James L, 2014, 'TRIM protein domain topology and implications for antiviral immunity', Acta Crystallographica Section A Foundations and Advances, 70, pp. C243 - C243,
    Journal articles | 2014
    Kumar KK; Jacques DA; Guss JM; Gell DA, 2014, 'The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 1032 - 1037,
    Journal articles | 2014
    Price A; Jacques D; Essig S; Elliott T; Halambage U; Chin J; Aiken C; James L, 2014, 'HIV-1 capsid binds host cofactors to mediate nuclear import', Acta Crystallographica Section A Foundations and Advances, 70, pp. C120 - C120,
    Journal articles | 2014
    Price AJ; Jacques DA; McEwan WA; Fletcher AJ; Essig S; Chin JW; Halambage UD; Aiken C; James LC, 2014, 'Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly', PLoS Pathogens, 10,
    Journal articles | 2014
    Tam JCH; Jacques DA, 2014, 'Intracellular immunity: Finding the enemy within-how cells recognize and respond to intracellular pathogens', Journal of Leukocyte Biology, 96, pp. 233 - 244,
    Journal articles | 2013
    Gadd MS; Jacques DA; Nisevic I; Craig VJ; Kwan AH; Guss JM; Matthews JM, 2013, 'A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions', Journal of Biological Chemistry, 288, pp. 21924 - 21935,
    Journal articles | 2013
    Rasaiyaah J; Tan CP; Fletcher AJ; Price AJ; Blondeau C; Hilditch L; Jacques DA; Selwood DL; James LC; Noursadeghi M; Towers GJ, 2013, 'HIV-1 evades innate immune recognition through specific cofactor recruitment', Nature, 503, pp. 402 - 405,
    Journal articles | 2013
    Vandevenne M; Jacques DA; Artuz C; Nguyen CD; Kwan AH; Segal DJ; Matthews JM; Crossley M; Guss JM; Mackay JP, 2013, 'New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217', J Biol Chem, 288, pp. 10616 - 10627,
    Journal articles | 2012
    Gadd MS; Jacques DA; Guss JM; Matthews JM, 2012, 'Crystallization and diffraction of an Isl1-Ldb1 complex', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 1398 - 1401,
    Journal articles | 2012
    Jacques DA; Guss JM; Svergun DI; Trewhella J, 2012, 'Publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution', Acta Crystallographica Section D: Biological Crystallography, 68, pp. 620 - 626,
    Journal articles | 2012
    Jacques DA; Guss JM; Trewhella J, 2012, 'Reliable structural interpretation of small-angle scattering data from bio-molecules in solution - The importance of quality control and a standard reporting framework', BMC Structural Biology, 12,
    Journal articles | 2011
    Jacques DA; Langley DB; Hynson RMG; Whitten AE; Kwan A; Guss JM; Trewhella J, 2011, 'A novel structure of an antikinase and its inhibitor', Journal of Molecular Biology, 405, pp. 214 - 226,
    Journal articles | 2011
    Jacques DA; Langley DB; Kuramitsu S; Yokoyama S; Trewhella J; Guss JM, 2011, 'The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase', Acta Crystallographica Section D: Biological Crystallography, 67, pp. 105 - 111,
    Journal articles | 2011
    Kumar KK; Jacques DA; Pishchany G; Caradoc-Davies T; Spirig T; Malmirchegini GR; Langley DB; Dickson CF; Mackay JP; Clubb RT; Skaar EP; Guss JM; Gell DA, 2011, 'Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH', Journal of Biological Chemistry, 286, pp. 38439 - 38447,
    Journal articles | 2010
    Hynson RMG; Kwan AH; Jacques DA; MacKay JP; Trewhella J, 2010, '1H, 13C and 15N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis', Biomolecular NMR Assignments, 4, pp. 167 - 169,
    Journal articles | 2010
    Jacques DA; Trewhella J, 2010, 'Small-angle scattering for structural biology - Expanding the frontier while avoiding the pitfalls', Protein Science, 19, pp. 642 - 657,
    Journal articles | 2009
    Jacques DA; Streamer M; Rowland SL; King GF; Guss JM; Trewhella J; Langley DB, 2009, 'Structure of the sporulation histidine kinase inhibitor Sda from Bacillus subtilis and insights into its solution state', Acta Crystallographica Section D: Biological Crystallography, 65, pp. 574 - 581,
    Journal articles | 2008
    Jacques DA; Langley DB; Jeffries CM; Cunningham KA; Burkholder WF; Guss JM; Trewhella J, 2008, 'Histidine Kinase Regulation by a Cyclophilin-like Inhibitor', Journal of Molecular Biology, 384, pp. 422 - 435,
    Journal articles | 2008
    Jacques DA; Langley DB; Whitten AE; Jeffries CM; Trewhella J, 2008, 'Inhibition of histidine kinase A inBacillus subtilis: a neutron contrast variation study', Acta Crystallographica Section A Foundations of Crystallography, 64, pp. C214 - C214,
    Journal articles | 2008
    Langley DB; Jacques DA; Whitten A; Trewhella J, 2008, 'The KipI–KipA complex and histidine kinase regulation inBacillus subtilis', Acta Crystallographica Section A Foundations of Crystallography, 64, pp. C214 - C215,
    Journal articles | 2007
    Whitten AE; Jacques DA; Hammouda B; Hanley T; King GF; Guss JM; Trewhella J; Langley DB, 2007, 'The Structure of the KinA-Sda Complex Suggests an Allosteric Mechanism of Histidine Kinase Inhibition', Journal of Molecular Biology, 368, pp. 407 - 420,
    Journal articles | 2006
    Finnie KS; Jacques DA; McGann MJ; Blackford MG; Barbé CJ, 2006, 'Encapsulation and controlled release of biomolecules from silica microparticles', Journal of Materials Chemistry, 16, pp. 4494 - 4498,
  • Preprints | 2024
    Mitic I; Michie K; Jacques D, 2024, Assessing the Validity of Leucine Zipper Constructs Predicted in AlphaFold2.,
    Preprints | 2024
    Yu R; Phalora P; Li N; Böcking T; Jacques DA, 2024, The Human T-cell Leukemia Virus capsid protein is a potential drug target,
    Preprints | 2023
    Dickson CF; Hertel S; Ruan J; Ariotti N; Tuckwell A; Li N; Al-Izzi SC; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2023, Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores, ,
    Preprints | 2022
    Faysal KMR; Walsh JC; Renner N; Marquez CL; Shah V; Tuckwell AJ; Christie MP; Parker MW; Turville SG; James L; Towers GJ; Jacques DA; Boecking T, 2022, Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure,
    Preprints | 2022
    Zuliani Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Faysal KMR; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV, ,
    Preprints | 2020
    Lau D; Walsh J; Dickson C; Tuckwell A; Stear J; Hunter D; Bhumkar A; Shah V; Turville S; Sierecki E; Gambin Y; Böcking T; Jacques D, 2020, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy,
    Conference Papers | 2013
    Dickson CF; Jacques DA; Malmirchegini GR; Spirig T; Kumar KK; Mackay JP; Clubb RT; Guss JM; Gell DA, 2013, 'The domains of Staphylococcus aureus haemoglobin receptor, IsdH, cooperate to steal haem from human haemoglobin', in FEBS JOURNAL, WILEY-BLACKWELL, RUSSIA, Saint Petersburg, pp. 128 - 128, presented at 38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), RUSSIA, Saint Petersburg, 06 July 2013 - 11 July 2013,

2022-2024: NHMRC Ideas Grant GNT2013215 "Understanding how viruses overcome the nuclear pore complex, the gatekeeper of genomic access"

2020-2022: NHMRC Ideas Grant GNT1182212 "The HIV Capsid is a Functional Scaffold that Directs Bidirectional Cargo Transport"

2019-2024: Wellcome Trust Collaborator Award 214344/Z/18/Z "What is Special About Pandemic HIV-1? How Capsid Cofactor Interactions Regulate DNA Synthesis, Innate Immunity and Pandemic Potential"

2019-2021: NHMRC Project Grant GNT1158338 "Control of HIV Capsid Uncoating"

2019: ARC Linkage Infrastructure, Equipment and Facilities Grant LE190100165 "X-ray Facility for Protein Crystallography"

2018-2020: ARC Discovery Project DP180101384 "Regulation of DNA Synthesis and Host Evasion by Lentivirus Capsids"

2012-2017: NHMRC Early Career Fellowship GNT103652 "Proteins Involved in HIV Infection and Host Defense"