Dr Janet Newman

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Dr Janet Newman received her BSc (Hons) from the University of Sydney, and her PhD from the Swedish University of Agricultural Sciences, under the supervision of Carl-Ivar Brändén. After two post-docs and a stint in Biotech in the US Janet moved back to Australia to set up the Collaborative Crystallisation Centre (C3) for CSIRO in Melbourne.

Janet has been involved in many aspects of structural biology – developing new automation, designing new crystallisation screens and creating software tools. She has been a guest lecturer at many international courses, and is currently a Section Editor for Acta Crystallographica Section F and a Co-Editor for Acta Crystallographica D. She is a co-organiser of the Cold Spring Harbor Course in Diffraction Methods in Structural Biology.

E-mail

janet.newman@unsw.edu.au

Books | 2019

, 2019, Supercomputing Frontiers, Abramson D; de Supinski BR, (ed.), Springer International Publishing,
Book Chapters | 2019

Watkins CJ; Rosa N; Carroll T; Ratcliffe D; Ristic M; Russell C; Li R; Fazio V; Newman J, 2019, 'A Crystal/Clear Pipeline for Applied Image Processing', in Abramson D; DeSupinski BR (ed.), , SPRINGER INTERNATIONAL PUBLISHING AG, pp. 19 - 37,

Book Chapters | 2015

Fazio VJ; Peat TS; Newman J, 2015, 'Crystallization: Digging into the past to learn lessons for the future', in , pp. 141 - 159,
Journal articles | 2024

Joho Y; Royan S; Caputo AT; Newton S; Peat TS; Newman J; Jackson C; Ardevol A, 2024, 'Enhancing PET Degrading Enzymes: A Combinatory Approach', ChemBioChem, 25,

Journal articles | 2023

Rosa N; Watkins CJ; Newman J, 2023, 'Moving beyond MARCO', PLOS ONE, 18,

Journal articles | 2023

Sharma S; Chung CY; Uryu S; Petrovic J; Cao J; Rickard A; Nady N; Greasley S; Johnson E; Brodsky O; Khan S; Wang H; Wang Z; Zhang Y; Tsaparikos K; Chen L; Mazurek A; Lapek J; Kung PP; Sutton S; Richardson PF; Greenwald EC; Yamazaki S; Jones R; Maegley KA; Bingham P; Lam H; Stupple AE; Kamal A; Chueh A; Cuzzupe A; Morrow BJ; Ren B; Carrasco-Pozo C; Tan CW; Bhuva DD; Allan E; Surgenor E; Vaillant F; Pehlivanoglu H; Falk H; Whittle JR; Newman J; Cursons J; Doherty JP; White KL; MacPherson L; Devlin M; Dennis ML; Hattarki MK; De Silva M; Camerino MA; Butler MS; Dolezal O; Pilling P; Foitzik R; Stupple PA; Lagiakos HR; Walker SR; Hediyeh-Zadeh S; Nuttall S; Spall SK; Charman SA; Connor T; Peat TS; Avery VM; Bozikis YE; Yang Y; Zhang M; Monahan BJ; Voss AK; Thomas T; Street IP; Dawson SJ; Dawson MA; Lindeman GJ; Davis MJ; Visvader JE; Paul TA, 2023, 'Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer', Cell Chemical Biology, 30, pp. 1191 - 1210.e20,

Journal articles | 2022

Baker EN; Bond CS; Garman EF; Newman J; Read RJ; Van Raaij MJ, 2022, 'Submission of structural biology data for review purposes', IUCrJ, 9, pp. 1 - 2,

Journal articles | 2021

Abrahams G; Newman J, 2021, 'Data and Diversity Driven Development of a Shotgun Crystallisation Screen using the Protein Data Bank', ,

Journal articles | 2021

Abrahams G; Newman J, 2021, 'Data- and diversity-driven development of a Shotgun crystallization screen using the Protein Data Bank', ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 77, pp. 1437 - 1450,

Journal articles | 2021

Baker EN; Bond CS; Garman EF; Newman J; Read RJ; Van Raaij MJ, 2021, 'Submission of structural biology data for review purposes', Acta Crystallographica Section F: Structural Biology Communications, 77, pp. 435 - 436,

Journal articles | 2021

Baker EN; Bond CS; Garman EF; Newman J; Read RJ; van Raaij MJ, 2021, 'Submission of structural biology data for review purposes.', Acta Crystallogr F Struct Biol Commun, 77, pp. 435 - 436,

Journal articles | 2021

Caputo AT; Eder OM; Bereznakova H; Pothuis H; Ardevol A; Newman J; Nuttall S; Peat TS; Adams TE, 2021, 'Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins', Scientific Reports, 11,

Journal articles | 2021

Dong L; McKinstry WJ; Pan L; Newman J; Ren B, 2021, 'Crystal structure of fungal tannase from Aspergillus niger', ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 77, pp. 267 - 277,

Journal articles | 2021

Guo Z; Smutok O; Johnston WA; Walden P; Ungerer JPJ; Peat TS; Newman J; Parker J; Nebl T; Hepburn C; Melman A; Suderman RJ; Katz E; Alexandrov K, 2021, 'Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices', Nature Communications, 12,

Journal articles | 2021

Helliwell JR; Newman J; van Raaij MJ, 2021, 'Topical Reviews in Acta Crystallographica F Structural Biology Communications', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 77, pp. 385 - 385,

Journal articles | 2020

Dennis ML; Newman J; Dolezal O; Hattarki M; Surjadi RN; Nuttall SD; Pham T; Nebl T; Camerino M; Khoo PS; Monahan BJ; Peat TS, 2020, 'Crystal structures of human ENPP1 in apo and bound forms', Acta Crystallographica Section D: Structural Biology, 76, pp. 889 - 898,

Journal articles | 2020

Esquirol L; Peat TS; Sugrue E; Balotra S; Rottet S; Warden AC; Wilding M; Hartley CJ; Jackson CJ; Newman J; Scott C, 2020, 'Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application', Advances in Microbial Physiology, 76, pp. 129 - 186,

Journal articles | 2020

Klemm T; Ebert G; Calleja DJ; Allison CC; Richardson LW; Bernardini JP; Lu BGC; Kuchel NW; Grohmann C; Shibata Y; Gan ZY; Cooney JP; Doerflinger M; Au AE; Blackmore TR; van der Heden van Noort GJ; Geurink PP; Ovaa H; Newman J; Riboldi-Tunnicliffe A; Czabotar PE; Mitchell JP; Feltham R; Lechtenberg BC; Lowes KN; Dewson G; Pellegrini M; Lessene G; Komander D, 2020, 'Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2', EMBO Journal, 39,

Journal articles | 2020

Newman J; Nebl T; Van H; Peat TS, 2020, 'The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein', Acta Crystallographica Section F: Structural Biology Communications, 76, pp. 583 - 589,

Journal articles | 2020

Newman J; van Raaij MJ, 2020, 'Contamination or serendipity - doing the wrong thing by chance', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 76, pp. 391 - 391,

Journal articles | 2020

Newman J; van Raaij MJ, 2020, 'Innovation versus practice in biological crystallization', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 76, pp. 290 - 291,

Journal articles | 2020

Rosa N; Ristic M; Thorburn L; Abrahams GJ; Marshall B; Watkins CJ; Kruger A; Khassapov A; Newman J, 2020, 'Tools to Ease the Choice and Design of Protein Crystallisation Experiments', CRYSTALS, 10,

Journal articles | 2020

Wilson J; Ristic M; Kirkwood J; Hargreaves D; Newman J, 2020, 'Predicting the Effect of Chemical Factors on the pH of Crystallization Trials', iScience, 23,

Journal articles | 2019

Abrahams GJ; Newman J, 2019, 'BLASTing away preconceptions in crystallization trials', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75, pp. 184 - 192,

Journal articles | 2019

Dennis ML; Esquirol L; Nebl T; Newman J; Scott C; Peat TS, 2019, 'The evolving story of AtzT, a periplasmic binding protein', Acta Crystallographica Section D: Structural Biology, 75, pp. 995 - 1002,

Journal articles | 2019

Dennis ML; Morrow BJ; Dolezal O; Cuzzupe AN; Stupple AE; Newman J; Bentley J; Hattarki M; Nuttall SD; Foitzik RC; Street IP; Stupple PA; Monahan BJ; Peat TS, 2019, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', Structural Dynamics, 6,

Journal articles | 2019

Helliwell JR; Minor W; Weiss MS; Garman EF; Read RJ; Newman J; van Raaij MJ; Hajdu J; Baker EN, 2019, 'Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography', ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75, pp. 455 - 457,

Journal articles | 2019

Helliwell JR; Minor W; Weiss MS; Garman EF; Read RJ; Newman J; van Raaij MJ; Hajdu J; Baker EN, 2019, 'Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75, pp. 321 - 323,

Journal articles | 2019

Helliwell JR; Minor W; Weiss MS; Garman EF; Read RJ; Newman J; van Raaij MJ; Hajdu J; Baker EN, 2019, 'Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography', IUCRJ, 6, pp. 341 - 343,

Journal articles | 2019

Helliwell JR; Minor W; Weiss MS; Garman EF; Read RJ; Newman J; van Raaij MJ; Hajdu J; Baker EN, 2019, 'Findable Accessible Interoperable Re-usable (FAIR) diffraction data are coming to protein crystallography', JOURNAL OF APPLIED CRYSTALLOGRAPHY, 52, pp. 495 - 497,

Journal articles | 2019

Newman J; Caron K; Nebl T; Peat TS, 2019, 'Structures of the transcriptional regulator BgaR, a lactose sensor', Acta Crystallographica Section D: Structural Biology, 75, pp. 639 - 646,

Journal articles | 2019

Newman J; van Raaij MJ, 2019, 'Introducing Methods Communications, a new category of contributions to Acta Crystallographica F', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75, pp. 529 - 530,

Journal articles | 2019

van Raaij MJ; Newman J, 2019, 'Taking biological structure communications into the third dimension', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 75, pp. 663 - 664,

Journal articles | 2018

Bruno AE; Charbonneau P; Newman J; Snell EH; So DR; Vanhoucke V; Watkins CJ; Williams S; Wilson J, 2018, 'Classification of crystallization outcomes using deep convolutional neural networks', PLOS ONE, 13,

Journal articles | 2018

Esquirol L; Peat TS; Wilding M; Hartley CJ; Newman J; Scott C, 2018, 'A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. Strain ADP', PLoS ONE, 13,

Journal articles | 2018

Esquirol L; Peat TS; Wilding M; Liu JW; French NG; Hartley CJ; Onagi H; Nebl T; Easton CJ; Newman J; Scott C, 2018, 'An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme', Journal of Biological Chemistry, 293, pp. 7880 - 7891,

Journal articles | 2018

Esquirol L; Peat TS; Wilding M; Lucent D; French NG; Hartley CJ; Newman J; Scott C, 2018, 'Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841', PLoS ONE, 13,

Journal articles | 2018

Gu A; Marshall B; Rosa N; Ristic M; Newman J, 2018, 'Organizing a crystallization laboratory', JOURNAL OF APPLIED CRYSTALLOGRAPHY, 51, pp. 47 - 54,

Journal articles | 2018

Newman J; Sharp JA; Enjapoori AK; Bentley J; Nicholas KR; Adams TE; Peat TS, 2018, 'Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus', Acta Crystallographica Section F: Structural Biology Communications, 74, pp. 39 - 45,

Journal articles | 2018

Rosa N; Ristic M; Marshall B; Newman J, 2018, 'Cinder: keeping crystallographers app-y', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 74, pp. 410 - 418,

Journal articles | 2017

Davies C; Böttcher C; Boss PK; Peat T; Newman J, 2017, 'Understanding the control of grape berry ripening and developing opportunities for its manipulation', Acta Horticulturae, 1157, pp. 1 - 10,

Journal articles | 2017

Land N; De Seta G; Berti P, 2017, 'Meltdown', SGUARDO-RIVISTA DI FILOSOFIA, pp. 269 - 279,

Journal articles | 2017

Peat TS; Balotra S; Wilding M; Hartley CJ; Newman J; Scott C, 2017, 'High-resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase family of Toblerone fold enzymes', Applied and Environmental Microbiology, 83,

Journal articles | 2017

Silk MR; Newman J; Ratcliffe JC; White JF; Caradoc-Davies T; Price JR; Perrier S; Thompson PE; Chalmers DK, 2017, 'Parallel and antiparallel cyclic d/l peptide nanotubes', Chemical Communications, 53, pp. 6613 - 6616,

Journal articles | 2017

Wilding M; Peat TS; Kalyaanamoorthy S; Newman J; Scott C; Jermiin LS, 2017, 'Reverse engineering: Transaminase biocatalyst development using ancestral sequence reconstruction', Green Chemistry, 19, pp. 5375 - 5380,

Journal articles | 2017

Wilding M; Scott C; Newman J; Peat TS, 2017, 'Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 29 - 35,

Journal articles | 2017

Wilding M; Scott C; Peat TS; Newman J, 2017, 'X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 24 - 28,

Journal articles | 2017

Zabara A; Meikle TG; Newman J; Peat TS; Conn CE; Drummond CJ, 2017, 'The nanoscience behind the art of: In-meso crystallization of membrane proteins', Nanoscale, 9, pp. 754 - 763,

Journal articles | 2017

Zabara A; Meikle TG; Trenker R; Yao S; Newman J; Peat TS; Separovic F; Conn CE; Call MJ; Call ME; Landau EM; Drummond CJ, 2017, 'Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis', Crystal Growth and Design, 17, pp. 5667 - 5674,

Journal articles | 2016

Brewster JL; McKellar JLO; Finn TJ; Newman J; Peat TS; Gerth ML, 2016, 'Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae', Scientific Reports, 6,

Journal articles | 2016

Kryshtafovych A; Moult J; Baslé A; Burgin A; Craig TK; Edwards RA; Fass D; Hartmann MD; Korycinski M; Lewis RJ; Lorimer D; Lupas AN; Newman J; Peat TS; Piepenbrink KH; Prahlad J; van Raaij MJ; Rohwer F; Segall AM; Seguritan V; Sundberg EJ; Singh AK; Wilson MA; Schwede T, 2016, 'Some of the most interesting CASP11 targets through the eyes of their authors', Proteins: Structure, Function and Bioinformatics, 84, pp. 34 - 50,

Journal articles | 2016

Ren B; McKinstry WJ; Pham T; Newman J; Layton DS; Bean AG; Chen Z; Laurie KL; Borg K; Barr IG; Adams TE, 2016, 'Structural and functional characterisation of ferret interleukin-2.', Dev Comp Immunol, 55, pp. 32 - 38,

Journal articles | 2016

Wilding M; Peat TS; Newman J; Scott C, 2016, 'A β-alanine catabolism pathway containing a highly promiscuous ω-transaminase in the 12-aminododecanate-degrading Pseudomonas sp. strain AAC', Applied and Environmental Microbiology, 82, pp. 3846 - 3856,

Journal articles | 2015

Balotra S; Newman J; Cowieson NP; French NG; Campbell PM; Briggs LJ; Warden AC; Easton CJ; Peat TS; Scott C, 2015, 'X-Ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex', Applied and Environmental Microbiology, 81, pp. 470 - 480,

Journal articles | 2015

Balotra S; Warden AC; Newman J; Briggs LJ; Scott C; Peat TS, 2015, 'X-Ray structure and mutagenesis studies of the n-isopropylammelide isopropylaminohydrolase, AtzC', PLoS ONE, 10,

Journal articles | 2015

Knoblich K; Park S; Lutfi M; van 't Hag L; Conn CE; Seabrook SA; Newman J; Czabotar PE; Im W; Call ME; Call MJ, 2015, 'Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly', CELL REPORTS, 11, pp. 1184 - 1192,

Journal articles | 2015

Peat TS; Newman J; Balotra S; Lucent D; Warden AC; Scott C, 2015, 'The structure of the hexameric atrazine chlorohydrolase AtzA', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 710 - 720,

Journal articles | 2015

Ristic M; Rosa N; Seabrook SA; Newman J, 2015, 'Formulation screening by differential scanning fluorimetry: how often does it work?', ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 71, pp. 1359 - 1364,

Journal articles | 2015

Rosa N; Ristic M; Seabrook SA; Lovell D; Lucent D; Newman J, 2015, 'Meltdown: A Tool to Help in the Interpretation of Thermal Melt Curves Acquired by Differential Scanning Fluorimetry', JOURNAL OF BIOMOLECULAR SCREENING, 20, pp. 898 - 905,

Journal articles | 2015

Warden AC; Williams M; Peat TS; Seabrook SA; Newman J; Dojchinov G; Haritos VS, 2015, 'Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst', Nature Communications, 6,

Journal articles | 2014

Balotra S; Newman J; French NG; Briggs LJ; Peat TS; Scott C, 2014, 'Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 310 - 315,

Journal articles | 2014

Boersma YL; Newman J; Adams TE; Cowieson N; Krippner G; Bozaoglu K; Peat TS, 2014, 'The structure of vanin 1: A key enzyme linking metabolic disease and inflammation', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 3320 - 3329,

Journal articles | 2014

Calero G; Cohen AE; Luft JR; Newman J; Snell EH, 2014, 'Identifying, studying and making good use of macromolecular crystals', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 993 - 1008,

Journal articles | 2014

Dennis ML; Chhabra S; Wang ZC; Debono A; Dolezal O; Newman J; Pitcher NP; Rahmani R; Cleary B; Barlow N; Hattarki M; Graham B; Peat TS; Baell JB; Swarbrick JD, 2014, 'Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from staphylococcus aureus', Journal of Medicinal Chemistry, 57, pp. 9612 - 9626,

Journal articles | 2014

Fazio VJ; Peat TS; Newman J, 2014, 'A drunken search in crystallization space', Acta Crystallographica Section F: Structural Biology Communications, 70, pp. 1303 - 1311,

Journal articles | 2014

Jackson CJ; Coppin CW; Carr PD; Aleksandrov A; Wilding M; Sugrue E; Ubels J; Paks M; Newman J; Peat TS; Russell RJ; Field M; Weik M; Oakeshott JG; Scott C, 2014, '300-fold increase in production of the Zn²⁺-dependent dechlorinase trzN in soluble form via apoenzyme stabilization', Applied and Environmental Microbiology, 80, pp. 4003 - 4011,

Journal articles | 2014

Kenny PW; Newman J; Peat TS, 2014, 'Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 565 - 571,

Journal articles | 2014

Luft JR; Newman J; Snell EH, 2014, 'Crystallization screening: The influence of history on current practice', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 835 - 853,

Journal articles | 2014

Mele K; Lekamge BMT; Fazio VJ; Newman J, 2014, 'Using time courses to enrich the information obtained from images of crystallization trials', Crystal Growth and Design, 14, pp. 261 - 269,

Journal articles | 2014

Mele K; Li R; Fazio VJ; Newman J, 2014, 'Quantifying the quality of the experiments used to grow protein crystals: The iQC suite', Journal of Applied Crystallography, 47, pp. 1097 - 1106,

Journal articles | 2014

Newman J; Peat TS; Paul Savage G, 2014, 'What's in a name? Moving towards a limited vocabulary for macromolecular crystallisation', Australian Journal of Chemistry, 67, pp. 1813 - 1817,

Journal articles | 2014

Peat TS; Dolezal O; Newman J; Mobley D; Deadman JJ, 2014, 'Interrogating HIV integrase for compounds that bind - A SAMPL challenge', Journal of Computer-Aided Molecular Design, 28, pp. 347 - 362,

Journal articles | 2013

Chan M; Fazio VJ; Newman J, 2013, 'Using graphs to represent crystallization conditions', Crystal Growth and Design, 13, pp. 1290 - 1294,

Journal articles | 2013

Chhabra S; Barlow N; Dolezal O; Hattarki MK; Newman J; Peat TS; Graham B; Swarbrick JD, 2013, 'Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK', PLoS ONE, 8,

Journal articles | 2013

Desbois S; Seabrook SA; Newman J, 2013, 'Some practical guidelines for UV imaging in the protein crystallization laboratory', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 201 - 208,

Journal articles | 2013

Dolezal O; Doughty L; Hattarki MK; Fazio VJ; Caradoc-Davies TT; Newman J; Peat TS, 2013, 'Fragment screening for the modelling community: SPR, ITC, and crystallography', Australian Journal of Chemistry, 66, pp. 1507 - 1517,

Journal articles | 2013

Newman J; Burton DR; Caria S; Desbois S; Gee CL; Fazio VJ; Kvansakul M; Marshall B; Mills G; Richter V; Seabrook SA; Wu M; Peat TS, 2013, 'Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 712 - 718,

Journal articles | 2013

Newman J; Seabrook S; Surjadi R; Williams CC; Lucent D; Wilding M; Scott C; Peat TS, 2013, 'Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli', PLoS ONE, 8,

Journal articles | 2013

Peat TS; Balotra S; Wilding M; French NG; Briggs LJ; Panjikar S; Cowieson N; Newman J; Scott C, 2013, 'Cyanuric acid hydrolase: Evolutionary innovation by structural concatenation', Molecular Microbiology, 88, pp. 1149 - 1163,

Journal articles | 2013

Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Paul Savage G; Francis CL; Deadman JJ, 2013, 'Correction: Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design (PLoS ONE)', PLoS ONE, 8,

Journal articles | 2013

Seabrook SA; Newman J, 2013, 'High-throughput thermal scanning for protein stability: Making a good technique more robust', ACS Combinatorial Science, 15, pp. 387 - 392,

Journal articles | 2013

Wielens J; Headey SJ; Rhodes DI; Mulder RJ; Dolezal O; Deadman JJ; Newman J; Chalmers DK; Parker MW; Peat TS; Scanlon MJ, 2013, 'Parallel screening of low molecular weight fragment libraries: Do differences in methodology affect hit identification?', Journal of Biomolecular Screening, 18, pp. 147 - 159,

Journal articles | 2012

Chhabra S; Dolezal O; Collins BM; Newman J; Simpson JS; Macreadie IG; Fernley R; Peat TS; Swarbrick JD, 2012, 'Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor', PLoS ONE, 7,

Journal articles | 2012

Darmanin C; Conn CE; Newman J; Mulet X; Seabrook SA; Liang YL; Hawley A; Kirby N; Varghese JN; Drummond CJ, 2012, 'High-throughput production and structural characterization of libraries of self-assembly lipidic cubic phase materials', ACS Combinatorial Science, 14, pp. 247 - 252,

Journal articles | 2012

Newman J; Bolton EE; Müller-Dieckmann J; Fazio VJ; Gallagher DT; Lovell D; Luft JR; Peat TS; Ratcliffe D; Sayle RA; Snell EH; Taylor K; Vallotton P; Velanker S; Von Delft F, 2012, 'On the need for an international effort to capture, share and use crystallization screening data', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 253 - 258,

Journal articles | 2012

Newman J; Dolezal O; Fazio V; Caradoc-Davies T; Peat TS, 2012, 'The DINGO dataset: A comprehensive set of data for the SAMPL challenge', Journal of Computer-Aided Molecular Design, 26, pp. 497 - 503,

Journal articles | 2012

Newman J; Luft JR, 2012, '13th international conference on the crystallization of biological macromolecules (ICCBM13) proceedings overview', Crystal Growth and Design, 12, pp. 3 - 7,

Journal articles | 2012

Newman J; Sayle RA; Fazio VJ, 2012, 'A universal indicator dye pH assay for crystallization solutions and other high-throughput applications', Acta Crystallographica Section D: Biological Crystallography, 68, pp. 1003 - 1009,

Journal articles | 2012

Peat TS; Böttcher C; Newman J; Lucent D; Cowieson N; Davies C, 2012, 'Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis', Plant Cell, 24, pp. 4525 - 4538,

Journal articles | 2012

Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2012, 'Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design', PLoS ONE, 7,

Journal articles | 2011

Atkinson SC; Dogovski C; Newman J; Dobson RCJ; Perugini MA, 2011, 'Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67, pp. 1537 - 1541,

Journal articles | 2011

Kennedy DF; Drummond CJ; Peat TS; Newman J, 2011, 'Evaluating protic ionic liquids as protein crystallization additives', Crystal Growth and Design, 11, pp. 1777 - 1785,

Journal articles | 2011

Newman J; Pearce L; Lesburg CA; Strickland C; Peat TS, 2011, 'Crystallization of an apo form of human arginase: Using all the tools in the toolbox simultaneously', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67, pp. 90 - 93,

Journal articles | 2011

Newman J, 2011, 'One plate, two plates, a thousand plates. How crystallisation changes with large numbers of samples', Methods, 55, pp. 73 - 80,

Journal articles | 2011

Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Le G; Jones ED; Smith JA; Coates JAV; Winfield LJ; Thienthong N; Newman J; Lucent D; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2011, 'Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design', Antiviral Chemistry and Chemotherapy, 21, pp. 155 - 168,

Journal articles | 2011

Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Newman J; Martyn J; Coates JAV; Ede NJ; Rea P; Deadman JJ, 2011, 'Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site', ChemBioChem, 12, pp. 2311 - 2315,

Journal articles | 2010

Chhabra S; Newman J; Peat TS; Fernley RT; Caine J; Simpson JS; Swarbrick JD, 2010, 'Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 575 - 578,

Journal articles | 2010

Dransfield DT; Cohen EH; Chang Q; Sparrow LG; Bentley JD; Dolezal O; Xiao X; Peat TS; Newman J; Pilling PA; Phan T; Priebe I; Brierley GV; Kastrapeli N; Kopacz K; Martik D; Wassaf D; Rank D; Conley G; Huang Y; Adams TE; Cosgrove L, 2010, 'A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo', Molecular Cancer Therapeutics, 9, pp. 1809 - 1819,

Journal articles | 2010

Ernberg K; McGrath AP; Peat TS; Adams TE; Xiao X; Pham T; Newman J; McDonald IA; Collyer CA; Guss JM, 2010, 'A new crystal form of human vascular adhesion protein 1', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 1572 - 1578,

Journal articles | 2010

Newman J; Fazio VJ; Lawson B; Peat TS, 2010, 'The C6 Web Tool: A resource for the rational selection of crystallization conditions', Crystal Growth and Design, 10, pp. 2785 - 2792,

Journal articles | 2010

Oakley AJ; Barrett S; Peat TS; Newman J; Streltsov VA; Waddington L; Saito T; Tashiro M; McKimm-Breschkin JL, 2010, 'Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses', Journal of Medicinal Chemistry, 53, pp. 6421 - 6431,

Journal articles | 2010

Robert R; Streltsov VA; Newman J; Pearce LA; Wark KL; Dolezal O, 2010, 'Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment', Protein Science, 19, pp. 299 - 308,

Journal articles | 2010

Taylor MC; Jackson CJ; Tattersall DB; French N; Peat TS; Newman J; Briggs LJ; Lapalikar GV; Campbell PM; Scott C; Russell RJ; Oakeshott JG, 2010, 'Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation', Molecular Microbiology, 78, pp. 561 - 575,

Journal articles | 2010

Vallotton P; Sun C; Lovell D; Fazio VJ; Newman J, 2010, 'DroplIT, an improved image analysis method for droplet identification in high-throughput crystallization trials', Journal of Applied Crystallography, 43, pp. 1548 - 1552,

Journal articles | 2009

Atkinson SC; Dobson RCJ; Newman JM; Gorman MA; Dogovski C; Parker MW; Perugini MA, 2009, 'Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 253 - 255,

Journal articles | 2009

Newman J; Cohen EH; Cosgrove L; Kopacz K; Dransfield DT; Adams TE; Peat TS, 2009, 'Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 945 - 948,

Journal articles | 2009

Newman J; Fazio VJ; Caradoc-Davies TT; Branson K; Peat TS, 2009, 'Practical aspects of the SAMPL challenge: Providing an extensive experimental data set for the modeling community', Journal of Biomolecular Screening, 14, pp. 1245 - 1250,

Journal articles | 2008

Dobson RCJ; Atkinson SC; Gorman MA; Newman JM; Parker MW; Perugini MA, 2008, 'The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, pp. 206 - 208,

Journal articles | 2008

Newman J; Pham TM; Peat TS, 2008, 'Phoenito experiments: Combining the strengths of commercial crystallization automation', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, pp. 991 - 996,

Journal articles | 2007

Newman J; Xu J; Willis MC, 2007, 'Initial evaluations of the reproducibility of vapor-diffusion crystallization', Acta Crystallographica Section D: Biological Crystallography, 63, pp. 826 - 832,

Journal articles | 2007

Thakur AS; Robin G; Guncar G; Saunders NFW; Newman J; Martin JL; Kobe B, 2007, 'Improved success of sparse matrix protein crystallization screening with heterogeneous nucleating agents', PLoS ONE, 2,

Journal articles | 2006

Newman J, 2006, 'A review of techniques for maximizing diffraction from a protein crystal in stilla', Acta Crystallographica Section D: Biological Crystallography, 62, pp. 27 - 31,

Journal articles | 2005

Badger J; Sauder JM; Adams JM; Antonysamy S; Bain K; Bergseid MG; Buchanan SG; Buchanan MD; Batiyenko Y; Christopher JA; Emtage S; Eroshkina A; Feil I; Furlong EB; Gajiwala KS; Gao X; He D; Hendle J; Huber A; Hoda K; Kearins P; Kissinger C; Laubert B; Lewis HA; Lin J; Loomis K; Lorimer D; Louie G; Maletic M; Marsh CD; Miller I; Molinari J; Muller-Dieckmann HJ; Newman JM; Noland BW; Pagarigan B; Park F; Peat TS; Post KW; Radojicic S; Ramos A; Romero R; Rutter ME; Sanderson WE; Schwinn KD; Tresser J; Winhoven J; Wright TA; Wu L; Xu J; Harris TJR, 2005, 'Structural analysis of a set of proteins resulting from a bacterial genomics project', Proteins: Structure, Function and Genetics, 60, pp. 787 - 796,

Journal articles | 2005

Newman J; Egan D; Walter TS; Meged R; Berry I; Jelloul MB; Sussman JL; Stuart DI; Perrakis A, 2005, 'Towards rationalization of crystallization screening for small- To medium-sized academic laboratories: The PACT/JCSG+ strategy', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 1426 - 1431,

Journal articles | 2005

Newman J, 2005, 'Expanding screening space through the use of alternative reservoirs in vapor-diffusion experiments', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 490 - 493,

Journal articles | 2005

Peat TS; Christopher JA; Newman J, 2005, 'Tapping the Protein Data Bank for crystallization information', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 1662 - 1669,

Journal articles | 2004

Newman J, 2004, 'Novel buffer systems for macromolecular crystallization', Acta Crystallographica Section D: Biological Crystallography, 60, pp. 610 - 612,

Journal articles | 2002

Adams JA; Jewell D; Jorgensen K; Mickley M; Newman JM, 2002, 'Image capture and analysis for macromolecular crystal growth using RoboMicroscope™ II', JALA - Journal of the Association for Laboratory Automation, 7, pp. 36 - 40,

Journal articles | 2002

Noland BW; Newman JM; Hendle J; Badger J; Christopher JA; Tresser J; Buchanan MD; Wright TA; Rutter ME; Sanderson WE; Müller-Dieckmann HJ; Gajiwala KS; Buchanan SG, 2002, 'Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme', Structure, 10, pp. 1569 - 1580,

Journal articles | 2002

Peat T; De la Fortelle E; Culpepper J; Newman J, 2002, 'From information management to protein annotation: Preparing protein structures for drug discovery', Acta Crystallographica Section D: Biological Crystallography, 58, pp. 1968 - 1970,

Journal articles | 2000

Marek J; Vevodova J; Smatanova IK; Nagata Y; Svensson LA; Newman J; Takagi M; Damborsky J, 2000, 'Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26', Biochemistry, 39, pp. 14082 - 14086,

Journal articles | 2000

Peat TS; Newman JM, 2000, 'Structural genomics in the post-genomics era: The shapes of things to come', Current Opinion in Drug Discovery and Development, 3, pp. 399 - 407

Journal articles | 1999

Newman J; Peat TS; Richard R; Kan L; Swanson PE; Affholter JA; Holmes IH; Schindler JF; Unkefer CJ; Terwilliger TC, 1999, 'Haloalkane dehalogenases: Structure of a Rhodococcus enzyme', Biochemistry, 38, pp. 16105 - 16114,

Journal articles | 1998

Peat TS; Newman J; Waldo GS; Berendzen J; Terwilliger TC, 1998, 'Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution', Structure, 6, pp. 1207 - 1214,

Journal articles | 1998

Ruscetti T; Newman J; Peat TS; Francis J; Nolan R; Terwilliger TC; Peterson SR; Lehnert BE, 1998, 'A nondenaturing purification scheme for the DNA-binding domain of poly(ADP-ribose) polymerase, a structure-specific DNA-binding protein', Protein Expression and Purification, 14, pp. 79 - 86,

Journal articles | 1998

Terwilliger TC; Waldo G; Peat TS; Newman JM; Chu K; Berendzen J, 1998, 'Class-directed structure determination: Foundation for a protein structure initiative', Protein Science, 7, pp. 1851 - 1856,

Journal articles | 1996

Rosenthal PB; Formanowski F; Treharne AC; Newman J; Skehel JJ; MeierEwert H; Wiley DC, 1996, 'Crystallization and preliminary X-ray diffraction studies of the influenza C virus glycoprotein', ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 52, pp. 1041 - 1045,

Journal articles | 1995

GUTTERIDGE S; NEWMAN J; HERRMANN C; RHOADES D, 1995, 'THE CRYSTAL-STRUCTURES OF RUBISCO AND OPPORTUNITIES FOR MANIPULATING PHOTOSYNTHESIS', JOURNAL OF EXPERIMENTAL BOTANY, 46, pp. 1261 - 1267,

Journal articles | 1994

Newman J; Gutteridge S, 1994, 'Structure of an effector-induced inactivated state of ribulose 1,5-bisphosphate carboxylase/oxygenase: the binary complex between enzyme and xylulose 1,5-bisphosphate', Structure, 2, pp. 495 - 502,

Journal articles | 1993

NEWMAN J; BRANDEN CI; JONES TA, 1993, 'STRUCTURE DETERMINATION AND REFINEMENT OF RIBULOSE 1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE FROM SYNECHOCOCCUS PCC6301', ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 49, pp. 548 - 560,

Journal articles | 1993

Newman J; Gutteridge S, 1993, 'The X-ray structure of Synechococcus ribulose-bisphosphate carboxylase/oxygenase-activated quaternary complex at 2.2-Å resolution', Journal of Biological Chemistry, 268, pp. 25876 - 25886

Journal articles | 1991

Newman JM; Binns M; Hambley TW; Freeman HC, 1991, 'Redetermination of the Crystal Structure of Hexaamminecobalt(II) Chloride', Inorganic Chemistry, 30, pp. 3499 - 3502,

Journal articles | 1990

NEWMAN JM; BEAR CA; HAMBLEY TW; FREEMAN HC, 1990, 'STRUCTURE OF BIS(GLYCINATO)ZINC(II) MONOHYDRATE, A 5-COORDINATE ZINC(II) COMPLEX', ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 46, pp. 44 - 48,

Journal articles | 1990

Newman J; Gutteridge S, 1990, 'The purification and preliminary X-ray diffraction studies of recombinant synechococcus ribulose-1,5-bisphosphate carboxylase/oxygenase from Escherichia coli', Journal of Biological Chemistry, 265, pp. 15154 - 15159
Preprints | 2022

Rosa N; Watkins C; Newman J, 2022, Moving beyond MARCO,

Conference Papers | 2018

Peat TS; Dennis M; Dolezal O; Newman J; Morrow B; Monahan B; Foitzik R; Khoo PS; Stupple P; Street I, 2018, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. A139 - A139,

Conference Papers | 2017

Thamali Lekamge BM; Sowmya A; Newman J, 2017, 'Prediction of protein X-ray crystallisation trial image time-courses', in ICPRAM 2017 - Proceedings of the 6th International Conference on Pattern Recognition Applications and Methods, pp. 663 - 668,

Conference Papers | 2013

Lekamge BMT; Sowmya A; Mele K; Fazio VJ; Newman J, 2013, 'Classification of protein crystallisation images using texture-based statistical features', in AIP Conference Proceedings, pp. 270 - 276,

Conference Papers | 2011

Vallotton P; Lovell D; Newman J, 2011, 'An observation about circular shortest paths: Dealing with additional constraints using branch and bound', in Proceedings - 2011 International Conference on Digital Image Computing: Techniques and Applications, DICTA 2011, pp. 513 - 517,

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