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Dr Jennie Cederholm

Dr Jennie Cederholm

Senior Lecturer
Medicine & Health
School of Biomedical Sciences
I have a MSc in Medical Biology from Linköping University, Sweden, and a PhD in Biomedical Sciences from the University of South Australia, Adelaide. I'm a Senior Lecturer and Head of Physiology teaching with a research focus on sensory neuroscience, in particular auditory neuroscience. 
I have a broad skillset and extensive knowledge in integrated cellular and systems electrophysiology, particularly in biophysical analysis of recombinant protein expression in neurons and evoked potential electrophysiology analysis of sensory circuits. This is complemented by expertise in transcriptomic analysis of gene regulation in response to physiological stimuli (auditory) and site-specific regulation of gene expression. I'm a co-inventor on a patent filing which is based on the discovery of purinergic hearing adaptation, a physiological response to moderate noise, which enables prediction of vulnerability to noise-induced hearing loss. This study is supported by a hearing diagnostics industry partner and by an international clinical study funded under the NHMRC Ideas grant scheme. I'm also a CI on two other category I funding grants (NHMRC and Australia's Economic Accelerator Seed grant) which supports two projects using Bionic-array Directed Gene Electrotransfer (BaDGE®) for treating focal brain disorders and wet age-related macular degeneration. 
I teach extensively across the UNSW Medicine and Science programs in the subject of Physiology and Neuroscience as an Education-focussed academic. I have a Graduate Certificate in University Learning and Teaching from UNSW Sydney and in 2021 I was awarded the Advanced Higher Education Fellowship. In 2022 I won the School of Biomedical Sciences Teacher of the Year award and in 2023 I won the Faculty of Medicine & Health Educator of the Year award, Educational Excellence award and the Heroes award (Elevate Team). I have supervised or co-supervised 3 ILP students and 7 Honours students and am currently co-supervising a Neuroscience Honours student and supervising a PhD student. 
I was the inaugural Chair of the UNSW Early Career Academic Network Executive Committee (ECAN-EC) and I'm the NSW Coordinator of the Australian Brain Bee Challenge since 2017. I'm currently the Co-lead of the Faculty of Medicine & Health Gender Equity group.
Phone
+61 2 9065 7495
E-mail
j.cederholm@unsw.edu.au
Location
Translational Neuroscience Facility, Level 3SW, Wallace Wurth, UNSW.
  • Journal articles | 2024
    Vlajkovic SM; Vélez-Ortega AC; Cederholm JME, 2024, 'Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection', Frontiers in Molecular Neuroscience, 17,
    Journal articles | 2023
    Housley GD; Nadar Ponniah PT; von Wegner F; Cederholm JM, 2023, 'Mouse models reveal P2X2 receptor-mediated hearing adaptation is an indicator of noise-induced hearing loss vulnerability', The Journal of the Acoustical Society of America, 154, pp. A298 - A298,
    Journal articles | 2023
    Sophocleous RA; Sluyter R; Gubert C; Vlajkovic SM; Cederholm JME, 2023, 'Third meeting of the Australian and New Zealand Purine Club', Purinergic Signalling, 19, pp. 595 - 598,
    Journal articles | 2022
    Cederholm JME; Parley KE; Perera CJ; von Jonquieres G; Pinyon JL; Julien JP; Ryugo DK; Ryan AF; Housley GD, 2022, 'Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice', Frontiers in Neurology, 13,
    Journal articles | 2022
    Gubert C; Sophocleous RA; Sluyter R; Vlajkovic SM; Cederholm JME, 2022, 'Second meeting of the Australian and New Zealand Purine Club', Purinergic Signalling, 18, pp. 385 - 386,
    Journal articles | 2022
    Sluyter R; Cederholm JME; Vlajkovic SM, 2022, 'Editorial: purinergic signalling—perspectives from Australia and New Zealand', Purinergic Signalling,
    Journal articles | 2020
    Housley GD; von Jonquieres G; Pinyon JL; Matheson JAT; Pearson LJ; Salthouse TP; Cederholm JM, 2020, 'Cochlear homeostasis: a molecular physiological perspective on maintenance of sound transduction and auditory neurotransmission with noise and ageing', Current Opinion in Physiology, 18, pp. 106 - 115,
    Journal articles | 2019
    Burnstock G; Cederholm JME; Sluyter R; Vlajkovic SM, 2019, 'Establishment and inaugural meeting of the Australian and New Zealand Purine Club', Purinergic Signalling, 15, pp. 313 - 314,
    Journal articles | 2019
    Cederholm JME; Kim Y; von Jonquieres G; Housley GD, 2019, 'Human Brain Region-Specific Alternative Splicing of TRPC3, the Type 3 Canonical Transient Receptor Potential Non-Selective Cation Channel', Cerebellum, 18, pp. 536 - 543,
    Journal articles | 2019
    Cederholm JME; Ryan AF; Housley GD, 2019, 'Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier’', Purinergic Signalling, 15, pp. 343 - 355,
    Journal articles | 2018
    von Jonquieres G; Spencer ZHT; Rowlands BD; Klugmann CB; Bongers A; Harasta AE; Parley KE; Cederholm J; Teahan O; Pickford R; Delerue F; Ittner LM; Fröhlich D; McLean CA; Don AS; Schneider M; Housley GD; Rae CD; Klugmann M; Froehlich D, 2018, 'Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy', Acta Neuropathologica, 135, pp. 95 - 113,
    Journal articles | 2015
    Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien J-P; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, 6, pp. 7115,
    Journal articles | 2015
    Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien J-P; Ryan AF; Housley GD, 2015, 'Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier', Nature Communications, 6,
    Journal articles | 2013
    Housley GD; Morton-jones R; Vlajkovic S; Telang RS; Paramananthasivam V; Tadros SF; Wong AC; Froud K; Cederholm JME; Sivakumaran Y; Snguanwongchai P; Khakh B; Cockayne DA; Thorne P; Ryan A, 2013, 'ATP-gated ion channels mediate adaptation to elevated sound levels.', Proceedings of the National Academy of Sciences of the United States of America, 110, pp. 7494 - 7499,
    Journal articles | 2012
    Cederholm JME; Froud K; Wong AC; Ko M; Ryan AF; Housley GD, 2012, 'Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse', Hearing Research, 292, pp. 71 - 79,
    Journal articles | 2010
    Cederholm JME; Absalom NL; Sugiharto S; Griffith R; Schofield PR; Lewis TM, 2010, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', Journal of Neurochemistry, 115, pp. 1245 - 1255,
    Journal articles | 2010
    Cederholm JME; Rychkov GY; Bagley CJ; Bretag AH, 2010, 'Inter-subunit communication and fast gate integrity are important for common gating in hClC-1', International Journal of Biochemistry and Cell Biology, 42, pp. 1182 - 1188,
    Journal articles | 2009
    Cederholm JME; Schofield PR; Lewis TM, 2009, 'Gating mechanisms in Cys-loop receptors', European Biophysics Journal, 39, pp. 37 - 49,
  • Patents | 2023
    Housley G; Cederholm J, 2023, Noise-induced hearing loss susceptibility test method and test apparatus, United States, Patent No. 11850044
    Preprints | 2021
    Cederholm JME; Parley KE; Perera CJ; von Jonquieres G; Pinyon JL; Julien J-P; Ryugo DK; Ryan AF; Housley GD, 2021, Association of cochlear outer hair cell - type II spiral ganglion afferents with protection from noise-induced hearing loss,
    Conference Presentations | 2020
    Cederholm J; Goulton C; Vickery R; Moorhouse A, 2020, 'Online peer assessment: Challenges, triumphs and lessons learnt during COVID-19', presented at UNSW Medicine & Health Education Forum, UNSW Sydney, 04 December 2020
    Conference Presentations | 2020
    Cederholm J; Goulton C; Vickery R; Moorhouse A, 2020, 'Our challenges and triumphs with online peer assessment in a fully remote course.', presented at Australian Physiological Society Education Forum, 25 November 2020
    Conference Presentations | 2020
    Cederholm J; Goulton C; Vickery R; Moorhouse A, 2020, 'Student Peer Assessment Using Moodle Workshop: Challenges in a COVID-19 world.', presented at UNSW Learning & Teaching Forum, 19 November 2020 - 20 November 2020
    Conference Abstracts | 2020
    Pearson L; Pinyon J; Von Jonquieres G; Cederholm J; Housley G, 2020, 'Characterising auditory neurons through transgene expression.', in Australasian Auditory Neuroscience Webinar, presented at Australasian Auditory Neuroscience Workshop
    Conference Abstracts | 2019
    Cederholm J, 2019, 'Electrically-evoked efferent suppression of the cubic DPOAE in Peripherin knockout mice confirms an intact medial olivocochlear reflex despite loss of contralateral suppression.', in Australasian Auditory Neuroscience Workshop, Adelaide, presented at Australasian Auditory Neuroscience Workshop, Adelaide
    Conference Abstracts | 2018
    Cederholm J; Ryan A; Housley G, 2018, 'Contribution of the cochlear amplifier to noise-induced purinergic hearing adaptation', in Australasian Auditory Neuroscience Workshop, Brisbane, presented at Australasian Auditory Neuroscience Workshop, Brisbane, 01 December 2018 - 01 December 2018
    Conference Abstracts | 2018
    Cederholm J; Ryan A; Housley G, 2018, 'Noise-induced hearing adaptation kinetics of the ‘cochlear amplifier’ maps to P2X2 receptor-dependent auditory brainstem response temporary threshold shift', in Proceedings of the Australian Physiology Society, Sydney, presented at Australian Physiology Society, Sydney, 25 November 2018 - 28 November 2018
    Conference Papers | 2018
    Cederholm JME; Ryan AF; Housley GD, 2018, 'Oral Communication: Purinergic hearing adaptation to sustained sound', in PURINERGIC SIGNALLING, SPRINGER, pp. S62 - S63,
    Conference Papers | 2018
    Housley GD; Ryan AF; Cederholm JME, 2018, 'Transcriptome profile of purinergic hearing adaptation', in PURINERGIC SIGNALLING, SPRINGER, pp. S61 - S61,
    Conference Abstracts | 2017
    Cederholm J; Perera C; Froud K; Wong A; Klugmann M; Sandow S; Julien J-P; Ryan A; Housley G, 2017, 'Contralateral versus ipsilateral suppression with knockout of a peripherin type III intermediate filament protein', in Australasian Auditory Neuroscience Workshop, Sydney, presented at Australasian Auditory Neuroscience Workshop, Sydney, 02 December 2017 - 02 December 2017
    Conference Abstracts | 2017
    Cederholm J; Ryan A; Housley G, 2017, 'Sustained sound elevation activates localised purinergic adaptation in the cochlea', in Australasian Neuroscience Society, Sydney, presented at Australasian Neuroscience Society, Sydney, 03 December 2017 - 07 December 2017,
    Conference Abstracts | 2016
    Housley G; Froud K; Cederholm J; Klugmann M; Julien J-P; Ryan A, 2016, 'Type II Spiral Ganglion Afferent Drive of the Medial Olivocochlear Reflex Reduces Hearing Loss from Acoustic Overstimulation', in Abstracts of the ... Midwinter Research Meeting / Association for Research in Otolaryngology. Association for Research in Otolaryngology (U.S.). Midwinter Research Meeting, San Diego, USA, presented at Association for Research in Otolaryngology 39th Annual MidWinter Meeting, San Diego, USA, 20 February 2016 - 24 February 2016,
    Conference Papers | 2016
    Perera C; Von Jonquieres G; Pinyon J; Parley K; Cederholm J; Julien J-P; Ryan A; Housley G, 2016, 'Phenotyping the differential innervation of the peripherin knockout mouse cochlea', in Proceedings of the Australian Physiological Society, Adelaide, presented at Australian Physiological Society, Adelaide, 04 December 2016 - 07 December 2016
    Conference Papers | 2015
    Cederholm J; Froud K; Wong A; Ryan A; Housley G, 2015, 'Assessing cochlear amplifier adaptation to noise', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 236 - 236, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015,
    Conference Abstracts | 2015
    Cederholm J; Froud K; Wong A; Ryan A; Housley G, 2015, 'Assessing cochlear amplifier adaptation to noise.', in Journal of Neurochemistry, Wiley, Cairns, Australia, Vol. 134, pp. 102 - 102, presented at 25th Biennial meeting of the International Society for Neurochemistry (ISN) jointly with the 13th meeting of the Asian-Pacific Society for Neurochemistry (APSN) in conjunction with the 35th meeting of the Australasian Neuroscience Society (ANS), Cairns, Australia, 23 August 2015 - 27 August 2015,
    Conference Abstracts | 2015
    Froud K; Cederholm J; Klugmann M; Julien J-P; Ryan A; Housley G, 2015, 'Cochlear type II spiral ganglion afferent fibres are essential for medial olivocochlear reflex-mediated otoprotection from noise-induced hearing loss', in Proceedings of the Australian Physiological Society, Hobart, presented at Australian Physiological Society, Hobart, 29 November 2015 - 02 December 2015
    Conference Abstracts | 2015
    Froud K; Wong A; Cederholm J; Klugmann M; Sandow S; Julien J-P; Ryan A; Housley G, 2015, 'The role of type II spiral ganglion afferent neurons in regulation of the cochlear amplifier.', in Kioloa at Newcastle Neuroscience Colloquium, Lake Macquarie, Newcastle, presented at Kioloa at Newcastle Neuroscience Colloquium, Lake Macquarie, Newcastle
    Conference Abstracts | 2015
    Housley G; Froud KE; Wong ACY; Cederholm JME; Klugmann M; Sandow SL; Julien J-P; Ryan AF, 2015, 'Sensory drive for medial olivocochlear efferent control of hearing balance depends upon type II spiral ganglion neuron innervation', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, Vol. 134, pp. 379 - 379, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015,
    Conference Papers | 2014
    Housley G; Cederholm J; Klugmann M; Ryan A, 2014, 'Purinergic signaling in the cochlea.', in Purinergic Signalling, Springer, Bonn, Germany, pp. 726 - 727, presented at Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, Germany, 23 July 2014,
    Conference Abstracts | 2014
    Housley GD; Cederholm JME; Klugmann M; Ryan AF, 2014, 'Purinergic signaling in the cochlea', in PURINERGIC SIGNALLING, SPRINGER, Vol. 10, pp. 726 - 727,
    Conference Abstracts | 2013
    Cederholm J; Froud K; Housley G, 2013, 'Cochlear gene expression analysis in response to noise stress in mice', in Proceedings of Australasian Neuroscience Society, Melbourne, presented at Australasian Neuroscience Society, Melbourne, 03 February 2013 - 06 February 2013,
    Conference Abstracts | 2013
    Cederholm J; Froud K; Kaplan W; Housley G, 2013, 'An analysis of noise-induced transcriptional responses in mice.', in Australasian Auditory Neuroscience Workshop, Melbourne, presented at Australasian Auditory Neuroscience Workshop, Melbourne
    Conference Abstracts | 2013
    Cederholm J; Froud K; Kaplan W; Ryan A; Housley G, 2013, 'Analysis of the gene expression response to a temporary reduction in hearing sensitivity', in Proceedings of the Australian Physiological Society, Geelong, presented at Australian Physiological Society, Geelong, 08 December 2013 - 11 December 2013
    Conference Abstracts | 2013
    Cederholm J; Froud K; Ryan A; Housley G, 2013, 'Mouse gene expression analysis following temporary threshold shift', in Proceedings of Society of Neuroscience, San Diego, USA, presented at Society of Neuroscience 2013, San Diego, USA, 09 November 2013 - 13 November 2013,
    Conference Presentations | 2013
    Cederholm JME; Froud K; Housley GD, 2013, 'Cochlear gene expression analysis in response to noise stress in mice.', presented at Australian Neuroscience Society meeting, Melbourne, Australia, 02 February 2013 - 06 February 2013
    Conference Presentations | 2013
    Cederholm JME; Froud K; Kaplan W; Housley GD, 2013, 'An analysis of noise-induced transcriptional responses in mice.', presented at Australasian Auditory Neuroscience Workshop, Melbourne, Australia, 02 February 2013
    Conference Abstracts | 2012
    Cederholm J; Froud K; Kaplan W; Housley G, 2012, 'Transcriptional responses to noise stress in mice', in Proceedings of Australian Physiology Society, Sydney, presented at Australian Physiology Society, Sydney, 02 December 2012 - 05 December 2012,
    Conference Presentations | 2012
    Cederholm JME; Froud K; Wong AC; Ko M; Housley GD, 2012, 'Isoflurane anaesthesia impacts on mouse hearing thresholds', presented at AuPS/ASCEPT/HBPRCA, Perth, 04 December 2012 - 07 December 2012
    Conference Abstracts | 2012
    Housley G; Froud K; Wong ACY; Cederholm J; Ryan A, 2012, 'Neurohumoral mechanisms for regulating sound transduction', in Australian Physiology Society Volume 43, Sydney, presented at Australian Physiology Society, Sydney, 02 December 2012 - 05 December 2012,
    Conference Presentations | 2011
    Cederholm J; Absalom N; Sugiharto S; Griffith R; Schofield P; Lewis T, 2011, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', presented at 23rd ISN-ESN Biennial Meeting, Athens, Greece, 28 August 2011 - 01 September 2011,
    Conference Abstracts | 2011
    Cederholm J; Sugiharto S; Schofield P; Lewis T, 2011, 'Investigating the role of loop 9 in glycine receptor signal transduction.', in Gage conference, presented at Gage conference
    Conference Abstracts | 2011
    Froud K; Wong ACY; Cederholm J; Klugmann M; Tadros S; Sandow S; Julien J-P; Ryan A; Housley G, 2011, 'The role of type II spiral ganglion neurons in the regulation of hearing sensitivity via the medial olivocochlear efferent pathway', in PROCEEDINGS OF THE AUSTRALIAN PHYSIOLOGICAL SOCIETY Volume 42, Perth, presented at Australian Physiological Society, Perth, 04 December 2011 - 07 December 2011,
    Conference Abstracts | 2011
    Housley G; Froud K; Wong A; Cederholm J; Vlajkovic S; Thorne P; Ryan A, 2011, 'Contribution of cochlear P2X2 receptors (ATP-gated ion channels) to hearing adaptation', in Molecular Biology of Hearing and Deafness conference, Cambridge, UK, presented at Molecular Biology of Hearing and Deafness conference, Cambridge, UK
    Conference Presentations | 2011
    Housley G; Froud K; Wong ACY; Cederholm J; Vlajkovic S; Thorne P; Ryan A, 2011, 'Contribution of cochlear P2X2 receptors (ATP-gated ion channels) to hearing adaptation', presented at Molecular Biology of Hearing and Deafness, Cambridge, UK.
    Conference Presentations | 2010
    Cederholm JME; Sugiharto S; Schofield PR; Lewis TM, 2010, 'Loop 9 residues adjacent to loop2 are involved in glycine receptor activation', presented at Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, 31 January 2010 - 03 February 2010
    Conference Abstracts | 2009
    Cederholm J; Absalom N; Sugiharto S; Griffith R; Schofield P; Lewis T, 2009, 'Loop 2 in the extracellular domain of the glycine receptor is involved in signal transduction', in Proceedings of Society for Neuroscience, Chicago, IL, USA., presented at Society for Neuroscience 2009, Chicago, IL, USA.
    Conference Abstracts | 2009
    Cederholm J; Absalom N; Sugiharto S; Kaplan W; Lewis T; Schofield P, 2009, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor', in Gage conference, presented at Gage conference
    Conference Abstracts | 2008
    Cederholm J; Absalom N; Sugiharto S; Kaplan W; Lewis T; Schofield P, 2008, 'Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor.', in The Australian Society for Biophysics, presented at The Australian Society for Biophysics
    Conference Abstracts | 2007
    Cederholm J; Rychkov G; Bretag A, 2007, 'The effect of mutation E232Q and clofibric acid derivatives on gating in the human skeletal muscle chloride ion channel, ClC-1', in Proceedings of the Australian Physiology Society, Newcastle, presented at Australian Physiology Society, Newcastle, 02 December 2007 - 05 December 2007,
    Conference Abstracts | 2006
    Cederholm J; Rychkov G; Duffield M; Bretag A, 2006, 'Effect of mutations on common gating in human ClC-1 chloride channels.', in ComBio conference, Brisbane, presented at ComBio conference, Brisbane
    Conference Abstracts | 2004
    Cederholm J; Rychkov G; Duffield M; Bretag A, 2004, 'The effect of mutations on slow gating in the human ClC-1 chloride channel.', in ComBio conference, Perth, presented at ComBio conference, Perth

My Research Supervision

I am currently supervising a PhD student in the auditory neuroscience field.Â