Dr Laurence Luu

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Laurence Luu is an adjunct associate lecturer in and research group. He is currently researching how the interactions between host immunogenetics and the microbiome leads to cancers of the gastrointestinal tract and inflammatory bowel disease.

Laurence previously completed his PhD in the under the supervision of and Dr. Sophie Octavia where he investigated the evolution of Bordetella pertussis to vaccines. During his PhD, he discovered new proteomic adaptations that were associated with increased fitness in the current Australian epidemic B. pertussis population. This discovery garnered widespread media attention and led to a national call to improve vaccines for whooping cough.

Laurence continued his research on whooping cough in the Evolutionary Microbiology lab as a postdoctoral researcher where he applied proteomics and functional genomics to better understand the biology and molecular pathogenesis of B. pertussis infections in order to improve��current vaccines and develop new treatments. He currently remains an honorary member of the lab.

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Professional Experience

2019 - Current: , Australian Society for Microbiology (ASM)

2018 - Current: Postdoctoral Research Associate, School of Biotechnology and Biomolecular Sciences, UNSW

2018 - PhD in Medical Microbiology and Immunology,��UNSW

2014 - Bachelor of Medical Science (Hons I), UNSW

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Awards

2019 -

2019 - ASM NSW-ACT Branch Postdoctoral Award

2018 -

2017 -

2017 - ASM NSW-ACT Branch Student Prize

Phone

+61-2-9385 3063

E-mail

laurence.luu@unsw.edu.au

Location

L4, Biological Sciences North D26

Journal articles | 2024

Luu LDW; Pandey A; Paramsothy S; Ngo C; Castaño-Rodríguez N; Liu C; Kamm MA; Borody TJ; Man SM; Kaakoush NO, 2024, 'Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice', Nature Communications, 15,

Journal articles | 2024

Luu LDW; Rafique R; Payne M; Octavia S; Robson J; Sintchenko V; Lan R, 2024, 'Deciphering Bordetella pertussis epidemiology through culture-independent multiplex amplicon and metagenomic sequencing.', J Clin Microbiol, pp. e0117824,

Journal articles | 2024

Majzoub ME; Luu LDW; Haifer C; Paramsothy S; Borody TJ; Leong RW; Thomas T; Kaakoush NO, 2024, 'Refining microbial community metabolic models derived from metagenomics using reference-based taxonomic profiling', mSystems, 9,

Journal articles | 2024

Strange N; Luu L; Ong V; Wee BA; Phillips MJA; McCaughey L; Steele JR; Barlow CK; Cranfield CG; Myers G; Mazraani R; Rock C; Timms P; Huston WM, 2024, 'HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit', Journal of Bacteriology, 206,

Journal articles | 2024

Wang Y; Yang S; Han B; Du X; Sun H; Du Y; Liu Y; Lu P; Di J; Luu LDW; Lv X; Hu S; Wang L; Jiang R, 2024, 'Single-cell landscape revealed immune characteristics associated with disease phases in brucellosis patients', iMeta, 3,

Journal articles | 2023

Haifer C; Luu LDW; Paramsothy S; Borody TJ; Leong RW; Kaakoush NO, 2023, 'Microbial determinants of effective donors in faecal microbiota transplantation for UC', Gut, 72, pp. 90 - 100,

Journal articles | 2023

Huang X; Li F; Wang Y; Jia X; Jia N; Xiao F; Sun C; Fu J; Chen M; Cui X; Qu D; Wai Luu LD; Tai J; Li J, 2023, 'Multi-omics analysis reveals underlying host responses in pediatric respiratory syncytial virus pneumonia', iScience, 26,

Journal articles | 2023

Jury B; Fleming C; Huston WM; Luu LDW, 2023, 'Corrigendum: Molecular pathogenesis of Chlamydia trachomatis (Frontiers in Cellular and Infection Microbiology, (2023), 13, (1281823), 10.3389/fcimb.2023.1281823)', Frontiers in Cellular and Infection Microbiology, 13,

Journal articles | 2023

Jury B; Fleming C; Huston WM; Luu LDW, 2023, 'Molecular pathogenesis of Chlamydia trachomatis', Frontiers in Cellular and Infection Microbiology, 13,

Journal articles | 2023

Luu LDW; Kasimov V; Phillips S; Myers GSA; Jelocnik M, 2023, 'Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of��chlamydial virulence, evolution, and phylogeny', Frontiers in Cellular and Infection Microbiology, 13,

Journal articles | 2023

Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2023, 'Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms', Frontiers in Microbiology, 14,

Journal articles | 2023

Wang Y; Huang X; Li F; Jia X; Jia N; Fu J; Liu S; Zhang J; Ge H; Huang S; Hui Y; Sun C; Xiao F; Cui X; Luu LDW; Qu D; Li J; Tai J, 2023, 'Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia', Critical Care, 27,

Journal articles | 2023

Wang Y; Luu LDW; Liu S; Zhu X; Huang S; Li F; Huang X; Guo L; Zhang J; Ge H; Sun Y; Hui Y; Qu Y; Wang H; Wang X; Na W; Zhou J; Qu D; Tai J, 2023, 'Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy', Signal Transduction and Targeted Therapy, 8,

Journal articles | 2023

Wang Y; Sun Q; Zhang Y; Li X; Liang Q; Guo R; Zhang L; Han X; Wang J; Shao L; Xue Y; Yang Y; Li H; Nie L; Shi W; Liu Q; Zhang J; Duan H; Huang H; Luu LDW; Tai J; Yang X; Wang G, 2023, 'Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas', Journal of Infection, 86, pp. 421 - 438,

Journal articles | 2023

Wang Y; Wang X; Jia X; Li J; Fu J; Huang X; Cui X; Wang B; Luo W; Lin C; Li Z; Luu LDW; Li S; Zhu X; Tai J, 2023, 'Influenza vaccination features revealed by a single-cell transcriptome atlas', Journal of Medical Virology, 95,

Journal articles | 2023

Yang X; Yan J; Xue Y; Sun Q; Zhang Y; Guo R; Wang C; Li X; Liang Q; Wu H; Wang C; Liao X; Long S; Zheng M; Wei R; Zhang H; Liu Y; Che N; Luu LDW; Pan J; Wang G; Wang Y, 2023, 'Single-cell profiling reveals distinct immune response landscapes in tuberculous pleural effusion and non-TPE', Frontiers in Immunology, 14,

Journal articles | 2022

Don Wai Luu L; Kaakoush NO; Castaño-Rodríguez N, 2022, 'The role of ATG16L2 in autophagy and disease', Autophagy, 18, pp. 2537 - 2546,

Journal articles | 2022

Haifer C; Paramsothy S; Kaakoush NO; Saikal A; Ghaly S; Yang T; Luu LDW; Borody TJ; Leong RW, 2022, 'Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial', The Lancet Gastroenterology and Hepatology, 7, pp. 141 - 151,

Journal articles | 2022

Huang X; Luu LDW; Jia N; Zhu J; Fu J; Xiao F; Liu C; Li S; Shu G; Hou J; Kang M; Zhang D; Xu Y; Wang Y; Cui X; Lai J; Li J; Tai J, 2022, 'Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus', Frontiers in Immunology, 13,

Journal articles | 2022

Li J; Luu LDW; Wang X; Cui XD; Huang X; Fu J; Zhu X; Li Z; Wang Y; Tai J, 2022, 'Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia', Emerging Microbes and Infections, 11, pp. 593 - 605,

Journal articles | 2022

Lu LDW; Singh H; Castaño-Rodríguez N; Leach ST; Riordan SM; Tedla N; Krishnan U; Kaakoush NO, 2022, 'Changes to the upper gastrointestinal microbiotas of children with reflux oesophagitis and oesophageal metaplasia', Microbial Genomics, 8,

Journal articles | 2022

Luu LDW; Lan R, 2022, 'Rapid Surface Shaving for Proteomic Identification of Novel Surface Antigens for Vaccine Development', , 2414, pp. 47 - 62,

Journal articles | 2022

Wang Y; Wang X; Luu LDW; Chen S; Jin F; Wang S; Huang X; Wang L; Zhou X; Chen X; Cui X; Li J; Tai J; Zhu X, 2022, 'Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine', Frontiers in Immunology, 13,

Journal articles | 2022

Wang Y; Wang X; Luu LDW; Li J; Cui X; Yao H; Chen S; Fu J; Wang L; Wang C; Yuan R; Cai Q; Huang X; Huang J; Li Z; Li S; Zhu X; Tai J, 2022, 'Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infection', Journal of Medical Virology, 94, pp. 5304 - 5324,

Journal articles | 2022

Xu Z; Hu D; Luu LDW; Octavia S; Keil AD; Sintchenko V; Tanaka MM; Mooi FR; Robson J; Lan R, 2022, 'Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis', Emerging Microbes and Infections, 11, pp. 1460 - 1473,

Journal articles | 2021

Li S; Huang J; Ren L; Jiang W; Wang M; Zhuang L; Zheng Q; Yang R; Zeng Y; Luu LDW; Wang Y; Tai J, 2021, 'A one-step, one-pot CRISPR nucleic acid detection platform (CRISPR-top): Application for the diagnosis of COVID-19', Talanta, 233,

Journal articles | 2021

Luu LDW; Payne M; Zhang X; Luo L; Lan R, 2021, 'Development and comparison of novel multiple cross displacement amplification (MCDA) assays with other nucleic acid amplification methods for SARS-CoV-2 detection', Scientific Reports, 11, pp. 1873,

Journal articles | 2021

Luu LDW; Zhong L; Kaur S; Raftery MJ; Lan R, 2021, 'Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation in Bordetella Biology and Virulence', Frontiers in Cellular and Infection Microbiology, 11,

Journal articles | 2021

Payne M; Octavia S; Luu LDW; Sotomayor-Castillo C; Wang Q; Tay ACY; Sintchenko V; Tanaka MM; Lan R, 2021, 'Enhancing genomics-based outbreak detection of endemic salmonella enterica serovar typhimurium using dynamic thresholds', Microbial Genomics, 7, pp. 000310,

Journal articles | 2021

Wang Y; Wang X; Wai Luu LD; Chen S; Jin F; Wang S; Huang X; Wang L; Zhou X; Chen X; Cui X; Li J; Tai J; Zhu X, 2021, 'Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine', ,

Journal articles | 2020

James LJ; Saglimbene V; Wong G; Tong A; Luu LDW; Craig J; Howard K; Howell M, 2020, 'Behavioural and pharmaceutical interventions for the prevention of skin cancers in solid organ transplant recipients: A systematic review of randomised controlled trials', BMJ Open, 10,

Journal articles | 2020

Kaur S; Peters T; Yang P; Luu LDW; Vuong J; Krycer J; O’Donoghue S, 2020, 'Temporal ordering of omics and multiomic events inferred from time series data', ,

Journal articles | 2020

Kaur S; Peters TJ; Yang P; Luu LDW; Vuong J; Krycer JR; O’Donoghue SI, 2020, 'Temporal ordering of omics and multiomic events inferred from time-series data', npj Systems Biology and Applications, 6,

Journal articles | 2020

Liu F; Chen S; Luu LDW; Lee SA; Tay ACY; Wu R; Riordan SM; Lan R; Liu L; Zhang L, 2020, 'Analysis of complete Campylobacter concisus genomes identifies genomospecies features, secretion systems and novel plasmids and their association with severe ulcerative colitis', Microbial Genomics,

Journal articles | 2020

Luu LDW; Octavia S; Aitken C; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2020, 'Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens', Vaccine, 38, pp. 539 - 548,

Journal articles | 2020

Wai Luu LD; Payne M; Zhang X; Luo L; Lan R, 2020, 'Development and comparison of a novel multiple cross displacement amplification (MCDA) assay with other nucleic acid amplification methods for SARS-CoV-2 detection', ,

Journal articles | 2019

Kamachi K; Otsuka N; Fumimoto R; Ozawa K; Yao SM; Chiang CS; Luu LDW; Lan R; Shibayama K; Watanabe M, 2019, 'A novel multilocus variable-number tandem repeat analysis for Bordetella parapertussis', Journal of Medical Microbiology, 68, pp. 1671 - 1676,

Journal articles | 2019

Luu LDW, 2019, 'Pathogen adaptation to vaccination: The Australian Bordetella pertussis story', Microbiology Australia, 40, pp. 177 - 180,

Journal articles | 2019

Xu Z; Octavia S; Luu LDW; Payne M; Timms V; Tay CY; Keil AD; Sintchenko V; Guiso N; Lan R, 2019, 'Pertactin-negative and filamentous hemagglutinin-negative Bordetella pertussis, Australia, 2013-2017', Emerging Infectious Diseases, 25, pp. 1196 - 1199,

Journal articles | 2018

Luu LDW; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Proteomic Adaptation of Australian Epidemic Bordetella pertussis', Proteomics, 18,

Journal articles | 2018

Wai Luu LD; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Comparison of the whole cell proteome and secretome of epidemic bordetella pertussis strains from the 2008–2012 Australian epidemic under sulfate-modulating conditions', Frontiers in Microbiology, 9,

Journal articles | 2017

Luu LDW; Octavia S; Zhong L; Raftery M; Sintchenko V; Lan R, 2017, 'Characterisation of the Bordetella pertussis secretome under different media', Journal of Proteomics, 158, pp. 43 - 51,

Journal articles | 2016

Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2016, 'Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study', Vaccine, 34, pp. 3967 - 3971,

Journal articles | 2015

Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2015, 'Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model', Vaccine, 33, pp. 6277 - 6281,
Preprints | 2024

Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2024, Proteomic comparison of epidemic AustralianBordetella pertussisbiofilm cells,

Conference Abstracts | 2022

Luu LD; Singh H; Castano-Rodriguez N; Leach ST; Stephen R; Tedla N; Krishnan U; Kaakoush NO, 2022, 'ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 162, pp. S833 - S833,

Conference Abstracts | 2022

Luu LD; Singh H; Castaño-Rodríguez N; Leach ST; Stephen R; Tedla N; Krishnan U; Kaakoush NO, 2022, 'Mo1603: ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', in Gastroenterology, Elsevier BV, Vol. 162, pp. S - 833,

Conference Papers | 2022

Luu LDW; Popple G; Tsang SPW; Vinasco K; Hilmi I; Ng RT; Chew KS; Wong SY; Riordan S; Lee WS; Mitchell HM; Kaakoush NO; Castaño-Rodríguez N, 2022, 'Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population', in Journal of Gastroenterology and Hepatology (Australia), pp. 342 - 351,

Preprints | 2022

Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2022, Integrating proteomic data with metabolic modelling provides insight into key pathways ofBordetella pertussisbiofilms,

Preprints | 2022

Xu Z; Hu D; Wai Luu LD; Octavia S; Keil A; Sintchenko V; Tanaka M; Mooi F; Robson J; Lan R, 2022, Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis,

Preprints | 2021

Wang Y; Wang X; Luu LDW; Li J; Cui X; Yao H; Zhang X; Chen S; Fu J; Wang L; Wang C; Yuan R; Cai Q; Huang X; Huang J; Xu W; Li S; Zhu X; Tai J, 2021, Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infection,

Preprints |

Wang Y; Li F; Huang X; Jia X; Jia N; Xiao F; Sun C; Fu J; Chen M; Cui X; Qu D; Luu LDW; Tai J; Li J, Integrated Proteomic and Metabolomic Analysis Reveals Underlying Host Responses in Pediatric Respiratory Syncytial Virus Pneumonia,

Preprints |

Wang Y; Luu LDW; Sun Q; Zhang Y; Li X; Liang Q; Guo R; Zhang L; Han X; Wang J; Shao L; Xue Y; Yang Y; Li H; Nie L; Shi W; Liu Q; Zhang J; Duan H; Huang H; Tai J; Yang X; Wang G, Tuberculosis Immune Landscapes Revealed by a Single-Cell Transcriptome Atlas: An Omics Study,

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