Dr Xin Jiang

Back to

Dr. Xin Jiang is a biochemist/structural biologist working on the mechanism investigation of membrane proteins. Mentored by Prof. Yigong Shi, Xin��was awarded his Ph.D. degree in 2017 from Tsinghua University, where he received systematic training in protein expression, purification, engineering, and characterization. He joined Prof. Nieng Yan's lab at Princeton University in 2018 for his postdoctoral training. During his postdoctoral period, Xin systematically revealed the molecular mechanism underlying the glucose and lactate transport cycle in human and Plasmodium. Later, Dr. Xin Jiang joined the BABS of UNSW in 2019 as a senior research fellow.��

E-mail

xin.jiang@unsw.edu.au

Journal articles | 2024

Chen L; Qi Q; Jiang X; Wu J; Li Y; Liu Z; Cai Y; Ran H; Zhang S; Zhang C; Wu H; Cao S; Mi L; Xiao D; Huang H; Jiang S; Wu J; Li B; Xie J; Qi J; Li F; Liang P; Han Q; Wu M; Zhou W; Wang C; Zhang W; Jiang X; Zhang K; Li H; Zhang X; Li A; Zhou T; Man J, 2024, 'Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2.', Cancer Discov, 14, pp. 1547 - 1565,

Journal articles | 2022

Jiang X; Yan N; Deng D; Yan C, 2022, 'Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect', IUBMB Life, 74, pp. 1180 - 1199,

Journal articles | 2022

Jiang X, 2022, 'An overview of the Plasmodium falciparum hexose transporter and its therapeutic interventions', Proteins: Structure, Function and Bioinformatics, 90, pp. 1766 - 1778,

Journal articles | 2022

Wang N; Zhang S; Yuan Y; Xu H; Defossa E; Matter H; Besenius M; Derdau V; Dreyer M; Halland N; He KH; Petry S; Podeschwa M; Tennagels N; Jiang X; Yan N, 2022, 'Molecular basis for inhibiting human glucose transporters by exofacial inhibitors', Nature Communications, 13,

Journal articles | 2021

Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, 2021, 'Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents', Proceedings of the National Academy of Sciences of the United States of America, 118,

Journal articles | 2021

Peng X; Wang N; Zhu A; Xu H; Li J; Zhou Y; Wang C; Xiao Q; Guo L; Liu F; Jia ZJ; Duan H; Hu J; Yuan W; Geng J; Yan C; Jiang X; Deng D, 2021, 'Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism', PLoS Biology, 19,

Journal articles | 2021

Wang N; Jiang X; Zhang S; Zhu A; Yuan Y; Xu H; Lei J; Yan C, 2021, 'Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates', Cell, 184, pp. 370 - 383.e13,

Journal articles | 2020

Gao M; Huang J; Jiang X; Yuan Y; Pang H; Luo S; Wang N; Yao C; Lin Z; Pu D; Zhang S; Sun P; Liu Z; Xiao Y; Wang Q; Hu Z; Yin H, 2020, 'Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters', Protein and Cell, 11, pp. 446 - 451,

Journal articles | 2020

Jiang X; Yuan Y; Huang J; Zhang S; Luo S; Wang N; Pu D; Zhao N; Tang Q; Hirata K; Yang X; Jiao Y; Sakata-Kato T; Wu JW; Yan C; Kato N; Yin H; Yan N, 2020, 'Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum', Cell, 183, pp. 258 - 268.e12,

Journal articles | 2019

Jiang X; Wu J; Ke M; Zhang S; Yuan Y; Lin JY; Yan N, 2019, 'Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs', Cell Discov, 5, pp. 14 - 14

Journal articles | 2017

Jiang X; Xu C; Lei F; Liao M; Wang W; Xu N; Zhang Y; Xie W, 2017, 'MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor', Scientific Reports, 7,

Journal articles | 2017

Ke M; Yuan Y; Jiang X; Yan N; Gong H, 2017, 'Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE', PLoS Comput. Biol., 13, pp. e1005603 - e1005603

Journal articles | 2016

Cui K; Zhang S; Jiang X; Xie W, 2016, 'Novel synergic antidiabetic effects of Astragalus polysaccharides combined with Crataegus flavonoids via improvement of islet function and liver metabolism', Molecular Medicine Reports, 13, pp. 4737 - 4744,

Journal articles | 2016

Ouyang X; Jiang X; Gu D; Zhang Y; Kong SK; Jiang C; Xie W, 2016, 'Dysregulated serum miRNA profile and promising biomarkers in dengue-infected patients', International Journal of Medical Sciences, 13, pp. 195 - 205,

Journal articles | 2016

TIAN CM; JIANG X; OUYANG XX; ZHANG YO; XIE WD, 2016, 'Berberine enhances antidiabetic effects and attenuates untoward effects of canagliflozin in streptozotocin-induced diabetic mice', Chinese Journal of Natural Medicines, 14, pp. 518 - 526,

Journal articles | 2015

Deng D; Sun P; Yan C; Ke M; Jiang X; Xiong L; Ren W; Hirata K; Yamamoto M; Fan S; Yan N, 2015, 'Molecular basis of ligand recognition and transport by glucose transporters', Nature, 526, pp. 391 - 396

Journal articles | 2015

Zhang S; Ouyang X; Jiang X; Gu D; Lin Y; Kong SK; Xie W, 2015, 'Dysregulated serum microRNA expression profile and potential biomarkers in hepatitis C virus-infected patients', International Journal of Medical Sciences, 12, pp. 590 - 598,

Journal articles | 2013

Zhang X; Xia M; Li Y; Liu H; Jiang X; Ren W; Wu J; DeCaen P; Yu F; Huang S; He J; Clapham DE; Yan N; Gong H, 2013, 'Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh', Cell Res., 23, pp. 409 - 422

Journal articles |

Jiang X; Smirnova I; Kasho V; Wu J; Hirata K; Ke M; Pardon E; Steyaert J; Yan N; Kaback HR, 'Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation', Proc. Natl. Acad. Sci. U.S.A., 113, pp. 12420 - 12425
Preprints | 2022

Jambeau M; Meyer K; Hruska-Plochan M; Tabet R; Lee C-Z; Ray-Soni A; Aguilar C; Savage K; Mishra N; Cavegn N; Borter P; Lin C-C; Jansen-West K; Jiang J; Freyermuth F; Li N; De Rossi P; Pérez-Berlanga M; Jiang X; Daughrity L; Pereira J; Narayanan S; Gu Y; Dhokai S; Dalkilic-Liddle I; Maniecka Z; Weber J; Workman M; McAlonis-Downes M; Berezovski E; Zhang Y-J; Berry J; Wainger B; Kankel M; Rushe M; Hock C; Nitsch R; Cleveland D; Petrucelli L; Gendron T; Montrasio F; Grimm J; Polymenidou M; Lagier-Tourenne C, 2022, Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease,

Preprints | 2021

Jahed Z; Yang Y; Tsai C-T; Foster E; McGuire A; Yang H; Liu A; Forro C; Yan Z; Jiang X; Zhao M-T; Zhang W; Li X; Li T; Pawlosky A; Wu J; Cui B, 2021, Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening,

Preprints | 2021

Raja W; Neves E; Burke C; Jiang X; Xu P; Rhodes K; Khurana V; Scannevin R; Chung CY, 2021, Patient-Derived Three-Dimensional Cortical Neurospheres to Model Parkinson’s Disease,

Preprints | 2020

Huang J; Yuan Y; Zhao N; Pu D; Tang Q; Zhang S; Luo S; Yang X; Wang N; Xiao Y; Zhang T; Liu Z; Sakata-Kato T; Jiang X; Kato N; Yan N; Yin H, 2020, Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents, ,

We are interested in understanding the molecular mechanism of membrane proteins and their therapeutic application. Specifically, we work on two different aspects of research fields.

The first aspect of our research interest is to reveal the function and mechanism of the plasmodium membrane proteins, followed by drug development. For instance, the plasmodium transporters play critical roles in absorbing nutrition, extruding metabolic waste, and maintaining osmotic balance. Inhibition of these membrane transport proteins can efficiently hamper the proliferation of plasmodium, which provides a novel path to cure malaria. Importantly, current clinical antimalarial agents are not targeting the membrane transporters. Therefore, the novel transporter inhibitors are promising medicines to fight against the multidrug-resistant plasmodium that increasingly threatens the campaign for malaria elimination.

The other research topic is in collaboration with senior lipid researchers in BABS. Currently, we try to understand the molecular mechanisms of several membrane proteins that play important roles in lipid and cholesterol biogenesis.

��

��������Ƶ

Follow

Dr Xin Jiang

��Ƶ